TOPIC 18 - marked, sorted and packaged into vesicles which...

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TOPIC 18: THE GOLGI APPARATUS For this lecture you need to study pp. 328 - 336 & Figs. 12.6 & 12.8 and to link this material with the preceding and the next lecture. Look over Fig. 12.7 but you are not expected to learn the details. The Golgi apparatus sorts, modifies and packages proteins in vesicles. Membranes and soluble proteins are moved to, through and away from the Golgi by transport vesicles. Vesicle development depends upon the construction of a protein coat. This lecture is truly an extension of the lecture on the ER. Please note the close relationship. The proteins which are produced on the rER and get 'dumped' into the cisternal space, get modified, usually glycosylated, before they are packaged into vesicles for export to the Golgi complex. In the Golgi apparatus proteins are further modified,
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Unformatted text preview: marked, sorted and packaged into vesicles which are marked for targeting to a particular place in the cell. Know for certain, basic structure and function of the Golgi complex, cis, medial, trans cisternae, trans Golgi network (TGN), VTCs and ERGIC, KDEL, M6P (mannose-6-phosphate). Please note (1) the vesicular transport model, (2) the cisternal maturation model and (3) the 'combined' model for the dynamics of transport through the Golgi complex. COP I, COP II, clathrin coated vesicles. You must be certain to link this lecture with the last lecture on the ER and the next lecture on the secretory pathway....
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