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TOPIC 20 - TOPIC 20 THE CELL CYCLE 554 556 cell cycle 586...

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TOPIC 20: THE CELL CYCLE 554 - 556, cell cycle 586 - 596 The cell cycle is the series of events that leads to the duplication and division of a cell, the production of two daughter cells that are accurate copies of the parent cell. The cell cycle integrates a continuous growth cycle with a discontinuous division cycle. You must understand the cell cycle very well. We will talk a little bit about the controls of the cell cycle but will not go into great detail and so what you might be tested on will be restricted to what I mention in lecture. These will include maturation-promoting factor ( MPF ) ( sometimes called mitosis promoting factor), which is a mitotic Cdk- cyclin complex. Know cyclin (G 1 cyclin (restriction point), G 2 cyclin (G2-M transition), and M cyclin, as well as cyclin -dependent kinases (Cdks). To gain a bit of insight into how these controls work we will look at G2-M transition in some detail. In general, the concentration of mitotic cyclin gradually increases during G1, S, and G2 until it reaches a threshold that triggers mitosis and then halfway through mitosis the M cyclin is rapidly destroyed.
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