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Unformatted text preview: Zoology 470 - Quiz #2 - 2008
This quiz has 10 questions and is worth a total of 10 points, and is designed to take 10 minutes. It is designed to test basic knowledge about signaling networks important in developmental biology. Use the accompanying answer sheet and a #2 pencil to enter your answers for the following multiple-choice questions. There is one right answer for each question. Please make sure you enter your student ID number on the answer sheet. 1. Which of the following is released in response to elevation of inositol trisphosphate (IP3)? a. Diacylglycerol (DAG) b. Calcium ions c. Cubitus interruptus (Ci) protein d. Smads e. None of the above 2. Cells respond to Wnt signaling using which type of receptor? a. Patched b. FGF receptor c. Steroid hormone receptor d. Frizzled e. none of the above 3. Which of the following pathways relies on elevation of -catenin to transduce its signals? a. Receptor tyrosine kinase signaling b. Wnt signaling c. Hedgehog signaling d. BMP signaling e. G protein-linked receptors 4. Gli3 is a vertebrate protein related to the cubitus interruptus (Ci) protein from flies. It acts as a transcriptional repressor in cells that have not received a certain type of signal. When cells receive this the signal, Gli3 becomes a transcriptional activator (i.e., it turns "on" the expression of genes). What signal is involved? a. Hedgehog b. Testosterone c. Wnt d. Notch e. fibroblast growth factor (FGF) 5. The Planar Cell Polarity (PCP) pathway is activated by what type of ligand? a. Hedgehog b. BMP c. Wnt d. Steroid hormone e. FGF Zoo 470 Quiz 2 2008 - Page 2 6. Which of the following is NOT usually true for growth factors? a. They act at short range b. Different cells respond differently to the same growth factor c. They can stimulate differentiation d. They are carried long distances in the bloodstream e. They are proteins 7. BMPs and other TGF- family growth factors function by activating which of the following? a. Ras b. Smads c. Tcf/Lef proteins d. -catenin e. None of the above 8. Which organelle serves as a main storage site for calcium ions? a. Lysosomes b. Ribosomes c. Phagosomes d. Endoplasmic reticulum e. Nucleolus 9. Which of the following is considered a "second messenger"? a. TGF- b. calcium ions c. FGF d. a & b e. a & c 10. In the Ras pathway, key proteins in the pathway are a particular type of enzyme. Which kind of enzyme are they? a. Phosphorylases b. Kinases c. Sulfatases d. Ubiquitin ligases e. None of the above ...
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- Spring '08