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prelab for friedel acytlation

prelab for friedel acytlation - Amrit Gupta PreLab for...

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Amrit Gupta 7/21/08 PreLab for Friedel-Crafts Acylation of Ferrocene Background/Chemistry of the Lab: This lab involves a Friedel-Crafts acylation. This involves an electrophilic aromatic substitution which brings an acyl group onto an aromatic group. The reaction should have this overall picture: Procedure: Acetic anhydride is corrosive so be aware of this. Its fumes are highly irritating, and it can react violently with water. Wear gloves and use the liquid under a hood. Avoid contact, do not breathe its vapors and keep it away from water. Phosphoric acid can cause serious burns, particularly to the eyes, skin or to clothing. Make sure that the glassware being used for the reaction is very dry. Clean a 10x100 mm reaction tube from the microscale kit, and then dry it in an oven briefly before beginning the experiment. Insert a short length of Teflon tubing (about an inch or two) into a rubber septum that fits on a 10x100 mm reaction tube. Begin heating a beaker of water on a hot plate. Place 0.28 g of ferrocene in the dry reaction tube. Using the markings on the reaction tube, add 1.0 mL of acetic anhydride to the ferrocene. Mix the contents of the tube to dissolve as much of the solid as you can.
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