picot statement and literature search - Running head...

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Running head: LITERATURE RESEARCH 1 Very good job overall! Literature Search Grand Canyon University: NRS-433V 03/19/2017
CLABSI PREVENTION Central Line associated Blood stream infections (CLABSI) is a primary laboratory confirmed bloodstream infection in a patient with a central line at the time of (or within 48-hours prior to) the onset of symptoms and the infection is not related to an infection from another site. Central line-associated bloodstream infections happen when a central line (a tube that a doctor usually places in a large vein of a patient’s neck or chest to give important medical treatment) is not put in correctly or not kept clean. This allows the central line to become a way for germs to enter the body and cause deadly infections in the blood. (CDC, 2016). Central line-associated bloodstream infections (CLABSIs) result in thousands of deaths each year and billions of dollars in added costs to the U.S. healthcare system, yet these infections are preventable type of health care associated infections (HAIs). CDC has provided guidelines and tools to the healthcare community to help end CLABSIs. (CDC, 2016). CLABSI is associated with increased morbidity and has mortality rates of 10 – 20%. The increase in medical cost is significant and is estimated at >$28,000 due to prolonged length of stay (mean of 7days).CLABSIs are serious but preventable infections when we understand the mechanism of why they happen and institute evidence based guidelines to combat them. It is unfortunate that CLABSI is still prevalent in the acute care setting and most commonly in ICU despite the use of preventive measures. CLABSI has always been the topic of interest for me as I have seen a lot of infection and has applied measures to prevent it. The strategies changes from time to time as per the evidence based practice to get the better outcome in our hospital where I work. One can hope that prevalence of CLABSI will be zero someday in future with extensive research of its measure for prevention. The following articles discuss about the existing condition of CLABSI and its prevalence with the use of preventive measures. 2
CLABSI PREVENTION Are antimicrobial peripherally inserted central catheters associated with reduction in central line–associated bloodstream infection? A systematic review and meta-analysis References Kramer, R. D., Conte, M., Mann, J., Saint, S., Chopra, V. (2017). Are antimicrobial peripherally inserted central catheters associated with reduction in central line–associated bloodstream infection? A systematic review and meta-analysis. American Journal of Infection Control, 45, 108-114. Background Antimicrobial peripherally inserted central catheters (PICCs) may reduce the risk of central line- associated bloodstream infection (CLABSI). However, data regarding efficacy are limited. We aimed to evaluate whether antimicrobial PICCs are associated with CLABSI reduction.

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