ProblemSet2 - Biochemistry 704 Problem Set 2 Due 02/26/2008...

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Biochemistry 704 Problem Set 2 Due 02/26/2008 1. Natural products are often derived from common building blocks. Which two of the 20 amino acids are precursors to penicillin? N S O H N R CO 2 H penicillin 2. Consider an α -helix and a β -hairpin ( i.e. , β -strand– β -turn– β -strand) of equal conformational stability and containing an equal number of amino acid residues. a. Which is likely to fold more quickly? Explain briefly. b. Which is likely to unfold more quickly? Explain briefly.
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page 2 of 5 3. A wild-type protein has a Δ G ° unfolding of 3 kcal/mol. An amino acid residue was replaced. This change had no effect on the free energy of the folded form of the protein, but lowered the free energy of the unfolded form by 5 kcal/mol. Is the native form of the variant protein more stable or less stable than that of the wild- type protein? Illustrate your answer with a free energy profile that shows the values of Δ G ° unfolding for the wild-type and variant proteins. 4.
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ProblemSet2 - Biochemistry 704 Problem Set 2 Due 02/26/2008...

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