Drug Class Review (Bingo) Fall 2012 - DRUG CLASS REVIEW PHARMACOLOGY Lynne Palma DNP FNP-BC CDE Fall 2012 THIS CLASS OF DRUGS Binds to muscarinic

Drug Class Review (Bingo) Fall 2012 - DRUG CLASS REVIEW...

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DRUG CLASS REVIEW PHARMACOLOGY Lynne Palma, DNP, FNP-BC, CDE Fall 2012
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THIS CLASS OF DRUGS Binds to muscarinic receptors Decreases heart rate Stimulates exocrine glands to increase sweating, salivation and bronchial secretion, and secretion of gastric acid Leads to bronchial constriction Relaxes the urinary sphincter Causes pupillary constriction (miosis) Is reversed with atropine
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What are Muscarinic Agonists (Parasympathomimetics) Bethanechol (Urecholine) Pilocarpine used for glaucoma
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THIS CLASS OF DRUGS Is used to lower BP Increases serum potassium Increases levels of bradykinins Dilates arteries and veins Can lead to a dry cough Generic version ends with “pril”
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WHAT ARE ANGIOTENSIN CONVERTING ENZYME INHIBITORS ACE inhibitors Quinapril (Accupril) Ramipril (Altace) Enalapril (Vasotec)
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THIS CLASS OF DRUGS Inhibits hepatic HMG-CoA reductase Increases the number of LDL receptors on hepatocytes Lowers LDL levels May elevate LFTs May lead to myopathy May cause life threatening rhabdomyolysis
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WHAT ARE HMG-CoA REDUCTASE INHIBITORS (STATINS) Atorvastatin (Lipitor) Simvastatin (Zocor) Pravastatin (Pravachol) Rosuvastatin (Crestor)
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THIS CLASS OF DRUGS Blocks the action of acetylcholine at muscarinic receptors Dilates the pupil leading to blurry vision, photophobia, and increased intraocular pressure Decreases the tone of the bladder leading to urinary retention, relaxes bronchial smooth muscle Decreases secretions from salivary glands Decreases tone and motility of the intestine leading to constipation Increases heart rate Serves as an antidote for muscarinic agonist poisoning
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WHAT ARE MUSCARINIC ANTAGONISTS (Parasympatholytics, antimuscarinics, anticholinergics) Atropine Ipratropium Bromide (Atrovent) Oxybutynin (Ditropan) Tolterodine (Detrol)
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THIS CLASS OF DRUGS Causes selective inhibition of COX- 2 Does not inhibit COX-1 Relieves inflammation without having an effect on the protective platelets in the stomach or kidneys Two of these agents were removed from the market in the past year
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WHAT ARE SECOND- GENERATION NSAIDS (COX-2 INHIBITORS) Celecoxib (Celebrex)
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THIS DRUG Decreases prostaglandin synthesis in the CNS Has analgesic and antipyretic properties Is devoid of antiinflammatory actions Does not alter platelets or cause gastric ulceration Can safely be used in children When mixed with alcohol, can deplete glutathione and lead to the accumulation of a toxic metabolite that can injure the liver
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WHAT IS ACETOMINOPHEN (TYLENOL)
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THIS CLASS OF DRUGS Promotes the synthesis of dopamine in the striatum Restores the proper balance between dopamine and ACh Can cause postural hypotension Can darken sweat and urine Is used to treat Parkinson’s disease
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WHAT ARE DOPAMINERGIC AGENTS Levodopa/Carbidopa (Sinemet)
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THIS DRUG Inhibits entry of sodium into hyperactive neurons to suppress activity Does not treat absence seizures
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