This preview shows page 1. Sign up to view the full content.
Unformatted text preview: used as a marker to identify them. Fluorescently labeled antibodies against BFABP are used to verify the presence of Schwann cells in normal tissue and their absence in the skin tissue in erbB3 mutant mice. Why was it important in these studies to show that erbB3 is not normally expressed in endothelial cells are they differentiate? It must be remembered that in the erbB3 mutant strain of mice, the erbB3 gene is defective in all cells of all tissues, not just in the Schwann cells. So the failure of arteriogenesis in erbB3 mice could also be explained if endothelial cells themselves need to express the erbB3 gene for their normal differentiation....
View Full Document
- Summer '08