CHAPTER 1 (Figures)

CHAPTER 1 (Figures) - David L. Nelson and Michael M. Cox...

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Lehninger Principles of Biochemistry Fourth Edition Chapter 1: The Foundations of Biochemistry David L. Nelson and Michael M. Cox
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Introduction Biochemistry is the science that deals with chemistry of living system. Why is Biochemistry important (Achievement of Biochem .) 1. The chemical basis of many central processes are understood. For example. The discovery of the d-helical structure of deoxyribonucleic acid (DNA). Elucidation of the flow of information from gene to protein. Determination of 3-D structure and mechanism of action of many protein molecules. The unraveling of the central metabolic pathways and energy conservation mechanism Development of recombinant DNA technology
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3 Introduction 2. Biochemistry has led to the knowledge that common molecular patterns and principles underlie the diverse expression of life. Examples include Organisms as different as bacterium E. Coli and human beings use the same building blocks to construct macromolecules. The flow of genetic information from DNA to ribonucleic acid (RNA) to protein is essentially the same in all organism. Adenosine triphosphate (ATP), the universal currency of energy in biological systems, is generated in similar ways by all forms of life. 3. Biochemistry is profoundly influencing medicine. Examples include The molecular mechanisms of many diseases, such as sickle-cell anemia and numerous inborn errors of metabolism, have been elucidated. Assays for enzyme activity are indispensable in clinical diagnosis. For example, the levels of certain enzymes in serum reveal whether a patient has recently had myocardial infarction. DNA probes are coming into play in the diagnosis of genetic disorders, infectious disease and cancer. Genetically engineered strains of bacteria containing recombinant DNA are
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4 Introduction 3. Biochemistry is profoundly influencing medicine. Examples include ( Cont ) Biochemistry is the basis for rational design of new drugs. Agriculture has and will benefit from recombinant DNA technology to produce designed changes in genetic endowment of organisms. 4. Development of powerful biochemical techniques and concepts has enabled investigators to tackle some of the most challenging and fundamental problems in biology and medicine. Examples include How does fertilized egg rise to cells as different as those in muscle, the brain and liver? How do cells find each other in forming a complex organ? How is the growth of cell controlled? What are causes of cancer? What is the mechanism of memory? What is the molecular basis of schizophrenia.
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5 Cellular Foundations Cells are the structural function units of all living organisms. The smallest organisms consist of a single microscopic cells
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This note was uploaded on 08/21/2008 for the course BIOCHEM 301 taught by Professor Vanes during the Spring '08 term at Rutgers.

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CHAPTER 1 (Figures) - David L. Nelson and Michael M. Cox...

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