04-18-08 - 4/18/08 METABOLIC PATHWAYS Metabolic Pathway A B...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
4/18/08 METABOLIC PATHWAYS Metabolic Pathway A ↔ B ↔ C ↔ D ……… ↔ J o each reaction (ex. A ↔ B) is catalyzed by a specific enzyme o there may also be branches in a metabolic pathway - Free Energy o ΔG overall is only dependent on A (start) and J (final product) NOT dependent on the nature of the intermediate reactions ΔG overall is the algebraic sum of ΔG A-B + ΔG B-C + …… - Rate o the overall rate of the above metabolic pathway is determined by the slowest reaction - Steady State o consider any intermediate, say B o the amount of B will depend on A ↔ B and B ↔ C o NOTE : this is not the normal equilibrium concentration attained if you only had A ↔ B Oxidation / Reduction - electrons from nutrients such as glucose or fatty acids + NAD + + H + NADH - NADH + 2e - + H + ½O 2 H 2 O - this sequence provides for the formation of the most ATP compared to any other reaction
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Phosphoryl Transferase - also provides for formation of ATP but minor to oxidation / reduction reactions Phosphoenol pyruvate (PEP) - the above reaction is known as substrate phosphorylation - the above reaction can be separated into two hydrolyses: Free Energies = ΔG° = -62 kJ / mol = ΔG° = -30.5 kJ / mol to get the complete reaction: you have to reverse the 2 nd reaction and then add it to the first reaction so you get ( ) so the overall
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 08/21/2008 for the course BIOCHEM 301 taught by Professor Vanes during the Spring '08 term at Rutgers.

Page1 / 5

04-18-08 - 4/18/08 METABOLIC PATHWAYS Metabolic Pathway A B...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online