04-04-08 - TRANSCRIPTION& TRANSLATIONRNAse...

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Unformatted text preview: 4-4-08TRANSCRIPTION & TRANSLATIONRNAse III-discovered by Hugh Robertsonin Zinder’s lab-RNAse III cleaves a section off-RNAse III cleaved dsRNA into 22 nucleotide-long sections and function was unknown-22 nucleotides – 2 turns of an RNA helix of dsRNAMicroRNA-acts to silence the mRNA -would form a double stranded structure but no a clean one-then an enzyme comes in and destroys the message-way to regulate RNA levels of mRNA-two pieces of mRNA mRNA1and mRNA2are made from the same strand of DNA but from different piecesothen mRNA1and mRNA2 come together to form a combinatorial RNA ligation-microRNA is a way to ligate(put two things together)ocleaving (separate two things) vs. ligate (put two things together)-messages are combinations of other messages-microRNA also serves as an adapter code to tell you which mRNA’s to put together before you even translateTranslation-when the DNA structure was proposed each turn of the helix had 10 nucleotides and so ½ a turn is made of 5 nucleotides-bases in this configuration: ohave a major groove and a minor groove and 10 nucleotides underneaththis allows things to come in and interactGamov’s Diamond Code-two of the bases of aa1overlap the coding for aa...
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04-04-08 - TRANSCRIPTION& TRANSLATIONRNAse...

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