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Week 5 - 1 Receptors Need to know Neurotransmitter...

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1 2/11/08 Receptors Need to know: Neurotransmitter synthesizing enzymes Synaptic vesicle transporters in pre-synaptic terminal Re-uptake transporters Degradative enzymes ( Glutamine, ACh, all of the catecholamines) Transmitter Gated Ion channels G-protiein gated channels Second messenger cascades. There are ionotropic/metabotropic ACh receptors. Loaded by ACh transporters. Breakdown of ACh. Choline is retransported using a sodium synport. – maintaining levels of neurotransmitters in the cell. Agonists/Antagonists Separating out what tissues .. why would a drug affect heart but not brain etc. (blood-brain barrier) What is more effective? AMPA receptors – CNQX APV(five) CURARE AND ATROPINE At Nor/epinephrine: Receptors: In general: alpha and beta varieties in receptor types. propranolol – an antagonist to beta receptors – consider this as an option when a patient is tachycardia or suffering from bradycardia. Keep in mind specific antagonists. GABA agonists/antagonists. GABAb ( note its antagonists) is specifically metabotropic receptors. elaborate on notes. Note: ATP is a new target as it binds to receptors both intra and extracellularly. There are two types of receptors – a types are found to be target of caffeine. Caffeine is inhibiting an inhibitory cell. phenylephrine – alpha receptors – similar to effedrin Recall: Glutamate receptors distinguished by agonists (NMDA, AMPA, Kainate) and these are divided into subtypes by antagonists. Subcellular processes of different types of receptors. AMPA – generally involved in depolarization
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2 NMDA – second messenger system. Dopamine has a tyrosine source. Is a catecholamine and is affected by monoamine oxidases. Nor/epinephrine Also a catecholamine. - Generally excitatory/ modulatory look this up. - Primarily in brain stem - Tyrosine precursor - Loaded in vesicles by VMATs - bind to G-protein coupled receptors * - Cleared by transporters (Na+) - Mono-amine oxidases. Nor/epinephrine are very specific. Ex. E could come down and there will affect the alpha and beta receptors. Then, NE could come and do the same but have completely opposite effects as E. They are both adrenaline. The distinction are the receptors. In parasympathetic system, NE has opposite affect of ACh. They have opposite functions – so is distinguished by the metabotropic receptors. adrenaline will have short term effects but in the brain, there are source neurons these neurons will also, when excited, engage autonomic system (breathing fast, pupils dilate) this system engages and continues to engage until it has to stop it before the next step. Next s is to talk to a few cells, talk to a couple of organs, the last step is to talk to the endocrine gland The body is freaking out, then sends a signal to the adrenal gland.
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