Bone2 - Ossification Bone forms in a process known as...

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Ossifcation Bone Forms in a process known as ossifcation.
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Bone Formation: Ossifcation Begins when mesenchymal cells become trans±ormed into osteoprogenitor cells. Give rise to cells that di±±erentiate into osteoblasts and osteoclasts. Two types o± ossifcation: intramembranous and endochondral.
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Intramembranous Ossifcation Intramembranous ossifcation occurs within loose fbrous connective tissue membranes oF the embryo and the adult. It Forms the ±at bones oF the skull, as well as the clavicles.
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4 Fetal Skeleton at 12 weeks Weeks
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Intramembranous Ossifcation Produces Fat bones o± skull, clavicle and mandible.
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Step 1: Differentiation of Mesenchymal Cells Mesenchyme condenses into a layer around the developing brain, forming a membrane. Mesenchymal cells differentiate into osteogenic cells (stem cells)
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Step 2: Osteoblasts Secrete Osteoid
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Step 3: Formation of Woven Bone and Bilaminar Periosteum
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Step 4: Thickened trabeculae form continuous plates of bone (spicules); these are replaced by compact bone. Intramembranous OssiFcation
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Endochondral Ossifcation Most bone Forms through endochondral bone growth. A hyaline model is Formed, which is then calcifed.
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11 Stages of Endochondral OssiFcation
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1. Cartilage model formation hyaline cartilage model is formed from mesenchyme covered with a perichondrium perichondrium produces chondrocytes and cartilage grows in thickness
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2. Formation of bone collar around the shaft of the hyaline cartilage model. Perichondrium stops producing chondrocytes and starts producing osteoblasts (now a periosteum) Bone collar produced by osteoblasts Primary ossi±cation center - region of chondrocyte enlargement Osteoblasts now secrete osteoid Epiphysis Diaphysis Primary ossi±cation
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This note was uploaded on 08/26/2008 for the course CBIO 2200 taught by Professor Wenzel during the Spring '08 term at University of Georgia Athens.

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Bone2 - Ossification Bone forms in a process known as...

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