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Muscle Contraction

Muscle Contraction - Muscle Contraction Relaxation...

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NEROMUSCULAR JUNCTION- Synapse o Functional connection between nerve fiber and its target cell (NM) o Acetylcholine (Ach) o Components of NMJ Synaptic knob (bouton) Synaptic cleft Motor end plate Junctional folds Synaptic vesicles Ach receptors Acetylcholinesterase (AChE) o Pharmacology of the NMJ o Botuslism toxin block exocytosis of the synaptic vesicles Botox o Curare blocks Ach receptors o Cholinesterase inhibitors Minor startle response can cause death neostigmine o Alpha-bungarotoxin Certain snake’s poison o Myasthenia gravis Disease where blocking of post-synaptic receptors occurs
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(use cholinesterase inhibitors for this disease) Brief Introduction to neuronal signaling o Plasma membrane is polarized Excess Na+ in ECF Excess K+ in ICF Overall= inside negatively charged when compared to the outside of a cell
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