Muscle Contraction - Muscle Contraction & Relaxation...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
NEROMUSCULAR JUNCTION- Synapse o Functional connection between nerve fiber and its target cell (NM) o Acetylcholine (Ach) o Components of NMJ Synaptic knob (bouton) Synaptic cleft Motor end plate Junctional folds Synaptic vesicles Ach receptors Acetylcholinesterase (AChE) o Pharmacology of the NMJ o Botuslism toxin block exocytosis of the synaptic vesicles Botox o Curare blocks Ach receptors o Cholinesterase inhibitors Minor startle response can cause death neostigmine o Alpha-bungarotoxin Certain snake’s poison o Myasthenia gravis Disease where blocking of post-synaptic receptors occurs
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
(use cholinesterase inhibitors for this disease) Brief Introduction to neuronal signaling o Plasma membrane is polarized Excess Na+ in ECF Excess K+ in ICF Overall= inside negatively charged when compared to the outside of a cell
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 08/26/2008 for the course CBIO 2200 taught by Professor Wenzel during the Spring '08 term at University of Georgia Athens.

Page1 / 4

Muscle Contraction - Muscle Contraction & Relaxation...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online