Andrea Lecture 1 - Extracellular Matrix Andrea I. Alford,...

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Extracellular Matrix Andrea I. Alford, Ph.D. Orthopaedic Research Laboratories aialford@umich.edu
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Extracellular Matrix Extracellular - outside the cell
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Extracellular Matrix Extracellular - outside the cell Matrix - “a surrounding substance within which something originates, develops, or is contained”
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Cells in all tissues secrete a specialized extracellular matrix Connective tissue ECM is abundant ECM bears load Epithelial and endothelial cells secrete a thin basement membrane Cells bear load:cell-cell juntions.
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Extracellular Matrix ECM contributes to tissue structural integrity ECM provides a scaffold for cell migration and tissue formation during development and wound healing BUT the ECM provides more than structure
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There is a dynamic-reciprocal relationship between cells and ECM ECM mediates changes in gene expression via mechanical and chemical pathways induced by transmembrane receptors Cells secrete ECM and regulate its assembly and degradation.
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Bone is an example of connective tissue ECM “Stacks” of type I collagen provide tensile strength
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Cartilage is an example of connective tissue matrix Proteoglycans resist compressive forces
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Tendon is an example of connective tissue matrix Parallel type I collagen fibers resist tensile forces
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Basement membranes form a thin mat Tissue specific permeability
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Basement membrane can separate epithelium from connective tissue E: epithelial cell BL: Basal Lamina C: Collagen
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ECM provides Scaffold for migration during development and wound healing structural integrity. BUT ECM is more than a scaffold.
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This note was uploaded on 09/06/2008 for the course BIOMEDE 418 taught by Professor Hunt during the Winter '08 term at University of Michigan.

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Andrea Lecture 1 - Extracellular Matrix Andrea I. Alford,...

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