10 The Nucleus - BME 418, Quantitative Cell Biology 10 -...

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BME 418, Quantitative Cell Biology Alan J. Hunt 10 - Protein Synthesis I: the Nucleus. Overview: Most cellular activities are performed by proteins. Manufacture and targeting is critical. How might proteins reach destinations? - diffusion (distance, specificity) - binding sites - active transport
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BME 418, Quantitative Cell Biology Alan J. Hunt Nucleus. With only a few exceptions (mitochondria, chloroplasts) protein manufacture starts in the nucleus. We won't dwell on details of transcription and translation since that's more the domain of a biochemistry or Molecular Bio. Course. Major components of the nucleus: - inner, outer membrane - lamina, intermediate filaments - nuclear pores - contains genetic material + transcription machinery The intermembrane space is contiguous with the lumen of the ER, and a web-like nuclear lamina is found just inside of the inner membrane. The nuclear lamina is made up of intermediate filaments.
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10 The Nucleus - BME 418, Quantitative Cell Biology 10 -...

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