12 Protein S and P III The Golgi

12 Protein S and P III The Golgi - BME 418, Quantitative...

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BME 418, Quantitative Cell Biology Alan J. Hunt #12: Protein Synthesis & Processing III: the Golgi and beyond.
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BME 418, Quantitative Cell Biology Alan J. Hunt Transport vesicles containing proteins in their lumen and membrane bud off the intermediate zone of the ER and move to the Golgi. - series of flattened membranous sacs - cis side nearest ER and nucleus, trans side nearest cell surface, medial in center - different regions contain different enzymes and perform specialized functions - proteins make their way from the cis to medial to trans golgi, and during this journey they undergo further modifications. - vesicles bud off the trans side and move away to other organelles or cell membrane; transport vesicles formed on the cis side move back to the ER, thereby allowing key membrane proteins (e.g. proteins involved in vesicle fusion, such as v-SNAREs) to be recycled. - upon reaching destination these vesicle fuse to membrane, dumping their contents and adding to the membrane. Until recently it was thought that proteins made their way from the cis to trans sides (anterograde transport) via transport vesicles that moved between the Golgi compartments. It now appears that this may only occur in the opposite, retrograde, direction, from trans to cis. But then how do proteins move from the cis to trans Golgi? It now seems that entire Golgi compartments make their way from the cis to trans side.
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This note was uploaded on 09/06/2008 for the course BIOMEDE 418 taught by Professor Hunt during the Winter '08 term at University of Michigan.

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12 Protein S and P III The Golgi - BME 418, Quantitative...

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