Lecture 5 bacterial flagella

Lecture 5 bacterial flagella - BME 418, Quantitative Cell...

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BME 418, Quantitative Cell Biology Alan J. Hunt Lecture #5: bacterial flagella, motility Bacterial Flagella: we've discussed how energy can be stored in a chemical or electrochemical gradient across a membrane, and in the example of lactose symport how this energy can be harnessed by a cell to perform useful work. What other sort of work can be accomplished in this way? In fact many things: a particularly striking example of how sophisticated this can become is the bacterial flagella, which allow bacteria to undergo movements that are much quicker and more controlled than diffusion. E. coli. only grow flagella in a nutrient starved environment (chemotaxis). Other taxis responses include: - Phototaxis - Aerotaxis - Magnetotaxis Components of flagellar structure are well established from biochemistry and molecular genetics: - make a mutant that has a motility failure - look for missing components of flagellar structure (light, EM) - use genetics to identify mutant sequence Flagella: - rigid helical rod - consist of one protein: flagellin At the base of flagella a hook inserts into the basal body. This structure rotates in the membrane. All components have been identified, but their function is still being worked out. Construction is accomplished by hierarchical operon induction. Bacteria can operate this way because bacterial mRNA can encode for more than one protein.
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This note was uploaded on 09/06/2008 for the course BIOMEDE 418 taught by Professor Hunt during the Winter '08 term at University of Michigan.

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Lecture 5 bacterial flagella - BME 418, Quantitative Cell...

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