Lecture 26 Flagella II - BME 418 Quantitative Cell Biology...

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BME 418, Quantitative Cell Biology Alan J. Hunt Lecture #26: Flagella II: experimental analysis using chlamydamonas Discussed last lecture: how the components of eukaryotic flagella give rise to flagellar beating. Other Axonemal structures need to be considered: - radial spokes - central microtubule pair - central pair rotation, distributing hypothesis and lack of helix. Other questions: - How is beating regulated (review bending)? - How are flagella assembled? - Structural details, e.g. two sets of dynein arms, doublet outer microtubules, radial spokes. Motility assays: - Advantages: controlled, defined, quantitative, controlled perturbations, and easier to interpret. Measurement examples - force, directionality, chemistry, geometry:
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BME 418, Quantitative Cell Biology Alan J. Hunt Disadvantage: May not be physiologic. For example isolated components of a complex structure such as flagella may only function in a meaningful way when in the context of the structure. Also, structural components may have specific assembly requirements that
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Lecture 26 Flagella II - BME 418 Quantitative Cell Biology...

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