Lecture 22 Signal Transduction II

Lecture 22 Signal Transduction II - BME 418, Quantitative...

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BME 418, Quantitative Cell Biology Alan J. Hunt Lecture #22: Signal Transduction continued. Transduction through protein kinase C - MAP kinase = mitogen-activated protein kinase. "Mitogen" refers to a signal that stimulates cell growth
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BME 418, Quantitative Cell Biology Alan J. Hunt Another common form of receptors are Receptor Tyrosine Kinases: - Receptor Tyrosine Kinases are typically activated by protein ligands that are typically hormones that regulate cell growth (e.g. insulin, growth factors). - EGF receptor illustrated (epidermal growth factor, a protein). - Upon binding ligand, receptors auto-phosphorylate, which activates them. - After auto-phosphorylation, receptor can bind and activate cytosolic enzymes.
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BME 418, Quantitative Cell Biology Alan J. Hunt Tyrosine kinase mediated signal transduction: - Activate two different types of pathways: 1) phospholipase C (this phospolipase is cytosolic and distinct from the one activated by G α ) 2) monomeric G-protein, Ras, through activation of GRB2-Sos.
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BME 418, Quantitative Cell Biology Alan J. Hunt Other pathways: - Pathways in T helper cells shown (incidentally, these are the principal cells that are attacked by AIDS). - Note that some familiar players, some unfamiliar since we've only covered the most common pathways. -
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This note was uploaded on 09/06/2008 for the course BIOMEDE 418 taught by Professor Hunt during the Winter '08 term at University of Michigan.

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Lecture 22 Signal Transduction II - BME 418, Quantitative...

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