Andrea Lecture 3 - Extracellular Matrix Andrea I. Alford,...

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Extracellular Matrix Andrea I. Alford, Ph.D. Orthopaedic Research Laboratories aialford@umich.edu
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Review idealized ECMs
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Dynamic reciprocity
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Cell-ECM interactions 2. ECM mediates changes in gene expression via mechanical and chemical pathways induced by transmembrane receptors 1. Cells secrete ECM and regulate its assembly and degradation. 4.ECM components regulate bioavailability of soluble factors 3. Proteases cleave ECM proteins leading to molecules with new biological activity 5. ECM components modulate each other’s interactions with cells; other matrix components
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Some real examples Integrin-ECM binding and downstream signaling is required for proper response to growth factors Fibronectin- α5β1 integrin binding leads to increased gap junction communication via MAP kinase in alveolar epithelium
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This is a theory for how ECM can help propagate order in tissues. Another example
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Basement membrane Permeability barrier Affects cells, too » Determine cell polarity » Influence cell metabolism » Direct cell migration » Induce cell differentiation
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Proteoglycans Composed of glycosaminoglycin (GAG) chain(s) and a core protein Bottle-brush appearance on EM
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This note was uploaded on 09/06/2008 for the course BIOMEDE 418 taught by Professor Hunt during the Winter '08 term at University of Michigan.

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Andrea Lecture 3 - Extracellular Matrix Andrea I. Alford,...

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