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lecture15 - OBJECTIVES Modeling and remodeling of bone...

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OBJECTIVES Modeling and remodeling of bone Age-related bone loss and repair Mechanical testing of bone.
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Modeling & Remodeling of Bone Stages in life of bone Involve three fundamental Processes Activation (A) Signals such as local damage/Death of osteocyte Resorption Osteoclasts take away or dissolve the damaged bone or bone with dead osteocytes Formation New bone formation by osteoblasts
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Why Model? Optimize shape and minimize resulting deformation To optimize bone Increase the size of the bone Change the shape of the bone
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Why Model? Increase the size of bone Osteoblast will form more bone
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Why Model? Change the shape of the bone Osteoclast will resorb bone and osteoblast will form bone – But the order doesn’t matter
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Why Model? Optimize shape and minimize resulting deformation
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Modeling Alteration in size or shape of bone by bone resorption and formation at different surfaces during growth Example
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Why Model?
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Remodeling
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