Asian Journal of Pharmaceutical Research and Development Vol.1 (4) July– August 2013:1-9 Malik Jony et al 0
Asian Journal of Pharmaceutical Research and Development Vol.1 (4) July– August 2013:1-9 Malik Jony et al 1 Asian Journal of Pharmaceutical Research and Development (An International Peer-Reviewed Journal of Pharmaceutical Research and Development) ISSN 2320-4850 Review Article HARD GELATIN CAPSULES (TWO PIECE) – A UNIQUE PHARMACEUTICAL DOSAGE FORM - AN EXHAUSTIVE REVIEW Jony Mallik *¹, Abdullah Al Faruq ¹, Hafsha Begum Chowdhury ², Md. Abu Monsur Dinar ³ ¹ Department of Pharmacy, Southern University Bangladesh, Chittagong ² Department of Pharmacy, University of Science & Technology Chittagong (USTC). ³ Executive- Quality Control (Quality Operation Department), Square Pharmaceuticals Ltd. Kaliakoir, Gazipur, Dhaka, Bangladesh Received: 02June 2013, Revised and Accepted: 04July 2013 ABSTRACT Pharmaceutical dosage form are the most vulnerable house to hold the medicament(s) along with excipients. From the ancient time to today, number of different dosage form included to pharmaceutical sciences. Every dosage form has distinct character in distributing, releasing & delivery of drug(s). Hence, dosage form play a very vital role for providing therapeutic responses. Capsule is the most popular solid unit dosage form having two types -Hard gelatin and Soft gelatin capsules. Hard gelatin capsules are extensively used as for dispensing many of the active pharmaceutical principles. Specially in case of manufacturing, Hard gelatin shell is required to encapsulate the mixed materials. Most instances, company purchased the shell from supplier. The integrity, thickness, locking quality of empty shell are important for quality capsules. Recently, modified pellets incorporates within shell for upgrading pharmaceutical purposes. Keywords: Pharmaceutical dosage form, Drug, Capsule, Hard gelatin capsules, Hard gelatin shell, Pellets. INTRODUCTION he word capsule is derived from the Latin word ‘Capsula’ which means a small box or container. The word is used to describe various natural and manmade materials in scientific discipline like in anatomy, as an enclosing membrane, in botany for fruit and in astrophysics for space vehicle. In pharmaceutical sciences, the word capsule is usually used to describe a solid dosage form that consists of a container usually made up of gelatin in which the medicinal substance is filled. *Corresponding Aouthor Jony Mallik Department of Pharmacy, Southern University Bangladesh, Chittagong Email: [email protected] Cellular: +8801830144424 In practice, the term empty capsule is used to describe the capsule containing no drug filled in it, rather, the container as raw material used to fill the drug in it.  Capsules are the solid preparation of hard or soft shell or container that contain mixed ingredients to make unit dose and usually meant for oral administration. They are of two types, hard and soft capsules. First patent was granted in 1834 for a method to produce a single-piece gelatin capsule. 
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