ct - Connective Tissue 1) supporting framework for all...

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Connective Tissue 1) supporting framework for all tissues and organs I. Characteristics - despite variability they all have: a) intercellular matrix i) amorphous ground substance = matrix ii) glycosaminoglycans (GAGs) - linear repeating disaccharide units iii) proteoglycans - protein backbone with GAGs attached b) extracellular fibers i) elastic - branched (1) major extracellular substance in two locations and stain purple with orcein (a) elastic ligaments arranged in fibers (b) elastic arteries arranged in fenestrated lamellae ii) collagenous - most abundant - high tensile strength (1) fibers made up of fibrils containing triple helix of 3 polypeptide chains (2) essential amino acids for helical structure = glycine, proline and 0H-proline iii) reticular - consists of collagen fibrils, silver stain identifies them (1) net arrangement around almost every cell (2) “rete” = net iv) fibrin - only seen during clotting c) cells - variable types depending on the C.T. i) Loose C.T. (1) Fibroblast - produces extracellular fibers (collagen and elastin) and ground substance (a) active secreting cells have high [rER] and basophilic cytoplasm (b) nucleus usually ovoid and flattened (c) Collagen synthesis: 3 steps
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This note was uploaded on 09/01/2008 for the course BIOL 4 taught by Professor Noble during the Fall '08 term at University of Louisville.

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ct - Connective Tissue 1) supporting framework for all...

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