Lect2bBB08notes

Lect2bBB08notes - Does DNA structure fulfill requirements ?...

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Traits can be transferred : Streptococcus pneumonia Intro to Biotech Lect.2 b What is the composition of a gene? What is the chemical nature of this heritable change ? How can we determine what a gene is? 1944 Avery - experimental system?
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• 1944 Avery - experimental system? What is the composition of a gene? “.... it takes alot of. ..evidence to convince anyone that the sodium salt of deoxyribonucleic acid could possibly be endowed with such biologically active and specific properties,” 1. 2. 3. 4. 5. Take home = Intro to Biotech Lect.2 b
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What is DNA? DNA - “deoxyribonucleic acid” 1. 2. 3. nitrogenous base a. b. 4. 5. Phosphodiester linkage 6. 7. A T, C G 8. Chargaff’s rules Why weak bonds? (H only 3% strength of covalent) 1. 2. Lect.2 Intro to Biotech Lect.2 b
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How is DNA organized?
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Unformatted text preview: Does DNA structure fulfill requirements ? 1. faithful replication 2. informational content 3. variation Heredity genes = Lect.2 Intro to Biotech Lect.2 b What are the molecular underpinnings of heredity? Heredity requires DNA to be passed on: How is DNA propagated? antiparallel double stranded helix hydrogen bonded base pairs replication mechanism: strand separation Faithful replication - molecular mechanism? Lect.2b Intro to Biotech How is DNA propagated ? Meselson and Stahl Experiment : grow bacteria in 15N (label DNA) grow one generation in 14N purify DNA run on cesium chloride gradient grow 2 generations in 14N purify DNA, run gradient Lect.2b Intro to Biotech...
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Lect2bBB08notes - Does DNA structure fulfill requirements ?...

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