quiz 3 - STUDENTID_ BIOBM331 QUIZ3a 9/19/07

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STUDENT ID ____________________ BIOBM331 QUIZ 3a 9/19/07 by which disulfide isomerase lowers the barrier for peptide disulfide interchange, given that: (RATE cat / RATE uncat ) = (exp - G o ± /RT ) cat / (exp - G o uncat R = 0.00832kJ/mol x K and T = 300K G o RATE cat /RATE uncat = 400. 2. (4 pts) Fill in the blanks below with the letter that best fits the description. You can use a letter more than once. N means native structure, or else α -helix for polyGlu. ____ polyGlu, pH << pKa ____ polyGlu, pH >> pKa ____ protein under physiological conditions ____ protein in 8M urea, with only the primary structure fully retained 3. (5 pts) Consider a schematic diagram of the native (folded) structure of a multi-fold protein : - - - - - Circle T if true, F if false, for each of the following statements about this diagram T/F Six polypeptides associating in IV (quaternary) structure are indicated T/F Shown is one single polypeptide, with a total of six folds T/F A single structural domain is shown, with transient IV structure indicated T/F This structure would be the most stable structure under physiological conditions T/F Shown is a transient IV complex 4. (8 pts) Circle T if true, F if false, for each of the following statements that compare a native, folded protein to the same protein, but unfolded in water: T/F H-bonds are generally more numerous in the folded protein than the unfolded T/F Higher temperature makes the hydrophobic interaction even stronger in driving folding T/F The single largest interaction that drives aqueous proteins to fold is the hydrophobic interaction T/F The folded protein must make essentially every possible H-bond T/F The favorable increase in water entropy drives proteins to fold T/F Under physiological conditions, G o of the native protein is lower than G o of any of the many unfolded structures T/F Electrostatic attractions are one key interaction that drives the unfolded protein to become folded in water.
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This note was uploaded on 09/08/2008 for the course BIOBM 3310 taught by Professor Feigenson,gw during the Fall '07 term at Cornell University (Engineering School).

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quiz 3 - STUDENTID_ BIOBM331 QUIZ3a 9/19/07

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