BIO 202 Lecture 7

BIO 202 Lecture 7 - Enzymes Regulation of Enzymes The...

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Enzymes, Regulation of Enzymes
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The catalytic cycle of an enzyme
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Properties of enzymes • Enzymes lower activation energy • Enzymes are substrate-specific (catalyze only specific reactions) • Enzymes are usually proteins – Exception is: • Ribozyme (RNA that cleaves RNA) • Enzymes are usually named by adding suffix “ASE” to the name of the substrate (i.e., sucrase , DNAse , phosphatase , cellulase )
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Rate of enzymatic reactions Amount of Substrate Rate Vmax Vmax/2 Km Enzymes always reach saturation
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Rate of enzymatic reactions • Vmax = maximum reaction rate (enzyme works at full capacity, usually when substrate is not limited) • Vmax/2 - one half of the maximum rate • Km - concentration of substrate at which enzyme works at half the maximum rate Km indicates how tightly the substrate is bound by the enzyme • increase substrate concentration => increase rate of reaction • Lower binding affinity = need more substrate to reach Vmax/2 (high Km) • High binding affinity = need less substrate to reach Vmax/2 (low Km) The lower the Km is the tighter the enzyme binds the substrate
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How do enzymes work? • They stretch and bend the critical bonds that
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This note was uploaded on 06/25/2008 for the course BI 202 taught by Professor Collins/cabot during the Fall '08 term at SUNY Stony Brook.

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BIO 202 Lecture 7 - Enzymes Regulation of Enzymes The...

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