Ford_PPT_Ch_09 - Introduction to Clinical Pharmacology Chapter 9 Antibacterial Drugs That Interfere With DNA\/RNA Synthesis Copyright 2014 Wolters Kluwer

Ford_PPT_Ch_09 - Introduction to Clinical Pharmacology...

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Introduction to Clinical Pharmacology Chapter 9 Antibacterial Drugs That Interfere With DNA/RNA Synthesis Introduction to Clinical Pharmacology Chapter 9 Antibacterial Drugs That Interfere With DNA/RNA Synthesis
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Fluoroquinolones Fluoroquinolones Ciprofloxacin (Cipro) Gemifloxacin (Factive) Levofloxacin (Levaquin) Moxifloxacin (Avelox) Norfloxacin (Noroxin)
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Fluoroquinolones: Actions Fluoroquinolones: Actions Bactericidal effect: Interfere with the synthesis of bacterial DNA Prevents cell reproduction, leading to death of the bacteria
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Fluoroquinolones: Uses Fluoroquinolones: Uses Used to treat infections caused by gram- positive and gram-negative microorganisms Used for the treatment of: Lower respiratory infections Bone and joint infections Urinary tract infections and infections of the skin Sexually transmitted diseases
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Fluoroquinolones: Adverse Reactions Fluoroquinolones: Adverse Reactions Common adverse effects: Nausea; diarrhea; headache; abdominal pain or discomfort; dizziness Serious adverse effects: Photosensitivity and hypersensitivity Bacterial or fungal superinfections Pseudomembranous colitis
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Fluoroquinolones: Contraindications and Precautions Fluoroquinolones: Contraindications and Precautions Contraindicated: In patients with a history of hypersensitivity; in children younger than 18 years; during pregnancy; in patients who cannot follow precautions regarding photosensitivity Used cautiously in: Patients with renal impairment; patients with history of seizures; geriatric patients; patients on dialysis
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Fluoroquinolones: Interactions Fluoroquinolones: Interactions Interactant drug Effect of interaction
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