Degenerative Joint Disease patho - Nichole Garlick Clinical...

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Nichole Garlick Clinical B – Mrs. Hoffer Degenerative Joint Disease Pathophysiology: A  degenerative disease of the  cartilage of joints. It is of diverse etiology and obscure  pathogenesis. Clinically, the disease is characterized by  joint pain, tenderness, limitation of movement, crepitus,  occasional effusion, and variable degrees of local  inflammation, but without systemic effects. Pathologically,  the disease is characterized by irregularly distributed loss of  cartilage (more frequent in areas of increased load),  sclerosis of subchondral bone, subchondral cysts, marginal  osteophytes, increased metaphyseal blood flow, and  variable synovial inflammation. Histologically, the disease  is characterized early by fragmentation of the cartilage  surface, cloning of chondrocytes, vertical clefts in the  cartilage, variable crystal deposition, remodeling, and  eventual violation of the tidemark by blood vessels. It is 
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