cell_phys_ex3 - Test 3 1. Most signaling pathways are... a....

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Unformatted text preview: Test 3 1. Most signaling pathways are... a. Linear only b. Branching only c. Converging only Branching and converging 2. Which o e following is TRUE about receptors? a. 1 receptors are proteins . All receptors are located in the plasma membrane c. Receptors can be activated only by binding soluble ligands ’ There are thousands of different receptor families in mammals Extracellular molecules X and Y bind to a plasma membrane receptor. Binding of molecule X results in changes in the cell’ behavior. Binding of molecule Y does not effect the cell’s behavior. 3. V‘x-‘iich olecule is an agonist? b. Y c. Neither X nor Y d. Both X and Y 4. Which molecule is an antagonist? a. X b. Y / c Neither X nor Y d. Both X and Y 5. Which molecule is a ligand? a. X b. Y c. Neither X nor Y 3. Both x and Y 6. Which of the following accurately describes RTK? I. Dimerization -) enzymatic activity of receptor II. RTKS are main receptors for interleukins _ III.- Tyrosine kinase domain lOcated extracellularly _ IV; TRK activates CAMP dependant signaling Q I only V b. IandlIonly 01L c. 1,III,rv ' 36 5 d. I,II,III,IV W) 6 ll? 7/741) Q)?” ,/L gylje . N . g t ,4 IL 6 K? ‘3 1 u 9 /\6 Ar 7. Which of the following describes the effects of phosphorylation of proteins? l. Phosphorylation typically occurs on serine and threonine residues 11. Phosphorylation creates binding sites 111. Phosphorylation can inhibit binding sites IV . Phosphorylation refers to addition of alpha phosphate residue from ATP or GTP a. 111, IV b I, 11, IV @1, 11, 111 ‘ god. II, III M ‘ «5 Pk (8 ??? inhibits 7-helix receptor by... ’W‘ a. X N“ b. x ®Blocking G protein interaction with receptor d. Stabilizing the testing rate conformation 9. The G—protein is active only when bound to GDP. 10. Which describes G-protein’s intrinsic GTPase activity? a. G-protein regulates its own gene expression G-protein hydrolyses GTP bound to terminate activity c. G-proteins phosphorylated themselves to induce enzymatic activity d. G-proteins self assemble and disassemble to regulate enzymatic activity 11. Which is TRUE concerning adapter proteins? Q Mediate interactions of proteins with molecule b. Are enzymes c. Both of the above d. None of the above 12. Which domain specifically recognizes phosphorylated tyrosines? é) ??? M2 b. 7?? c. PH stilt d. EVHl 13. Choose correct statement concerning 2nd messengers. a. Lipid derived 2nd messengers are produced by enzymes called cyclases b. CAMP is involved in signaling pathway by RTK c. PIP3 induces the release of Ca from intracellular stores @ DAG and 1P3 are derived from phospholipid PIP; l4. Adenylyl cyclase generated CAMP from... a. Adenosine b. 3’5’ AMP c. 5’ AMP ATP 15. This enzyme degrades CAMP. .. a. Protein kinase Phosphodiesterase c. Adenylyl cyclase d. Phosphorylase 16. Which is the cellular effecter of cAMP? a. 7?? proteosome protein kinase A c. Adenylyl cyclase d. Phosphorylase / NO relaxes smooth muscle by activating cGMP production 17. Whichfitement best describes 2"d messenger function of NO? b. NO regulates vasoconstriction thus increasing blood pressure c. NO stimulates release of epinephrine g 0 am a; d. NO release Ca from intracellular stores [00 V9le A ’ Matching receptor types U7 0 > ” V ’5’ \ . I 77 / 1] i 3 3:03am rec tor IQ ,XW .. o opsm w . 0 AS 20. Insulin receptor [7 4; 1’ 1 21. Beta-adrenergic receptorQ a. Ion channel receptor b. RTK c. Cytokine receptor d. GPCR 22. In pancreatic Beta cells, KM? ion channel closes in response to this ligand. a. Ca b. Insulin c. Glucose ATP 23. Which is the signal transduction step in insulin-signaling cascade? a. Binding of insulin to insulin receptor b. Desensitization of receptor @ Recruitment of IRS protein by an insulin receptor d. Insertion of GLUT 4 glucose uniporters in cell membrane 24. 25. 26. 27. 28. 29. 30. Which describes function of MAP Kinase in insulin signaling? a. Causes insulin receptors to dirnerize /§) Regulates transcription factors for GLUT 4 Mo Stimulates glutamate secretion d. Activates ecosanoids to produce prostaglandins Which describes the condition of photoreceptor cells in dark? a. Rods are hyperpolarized b. Retinol is not attached to rhodopsin @CGMP channels stay open allowing an influx ofNa and Ca d. bipolar cells are constantly activated Glutamate secretion is inhibited . Cell membrane gets depolarized c. cGMP gated channels open d. rhodopsin is phosphorylated What ha’igens when concentration of cGMP declines in photoreceptor cells? Molecular properties of extracellular matrix determined by... a. The types of extracellular matrix molecules b. Spatial arrangement of extracellular matrix molecules c. Hydration level of extracellular matrix molecules All ofthe above The basic unit of fibrillar callogen. .. / / Atriple helix /7 [6A coiled coil /’ A parallel homodimer ldf An antiparallel homodimer Homophilic interaction occurs between which of the following molecules? a. Integrin and fibronectin £9 N-cadherins on cells repressing similar N-cadherrins c. Selectin and mucin d. All of the above Which does NOT describe gap junctions? a. Act as size filters b. Integrate metabolism between cells c. Can be regulated by pH d. Are present in chemical synapses \ v 1. Which of‘the following is Normma ' A. FibroblaSt - it; " .. _- B. Mast cell C. Adipocyte ' '® Neu'trophil connective tissue cell? ' C. Proteoglycans D. Collagen 3- The cells that secrete hismifle-Cdfltaimng'granules in response to exposure to allergens are ' I , A. FibrOblasts. ' ...' . . = -_ @ Mast cells ' y C. ,AdipoCytes I D. Neutrophils 4. Adipocytes store fats in the form acids. ' ‘ ' ' 5. Molecular properties of the extracel é} matrlx are determined by A. The types of the extracellular matrix molecules B. Spatial arrangement of extracellular”: ‘lrikfinolecules C. Hydration level of extracellularmati'iii I‘le‘cules @All of the above _ " " .\;.':s'.;.«s hair “his. 3%. A. Fibroblasts B. Epithelial cells @9 Both of the above D. None of the above 7. Type I collagen is synthesized- A. Extracellularly i_ ' In the secretory pathway C. In the cytoplasm I " ‘ D. At the plasma membrane e) 8. Tertiary structur of collageni formed ' I @InER me waw'c" . I - :2, B. InGolgi _ wcflx\o\\lw\wI 83} C. Both of the above ‘ ‘ ‘ D. None of the above \‘ 9. galumnan is synthesized . - On the ER bound ribosomes ' @ On the free cytosolic ribosomes C. Both of the above : I . D. None ofthe above ' ,. I, ,I I a _ I I. » I_I-_. ' 10. Elasticity of the skin is greater in the young due to I . - - . ' " _ - ' ._‘ ' __ A. Lower elasticity of the collagen fibers ’ ' ' I ' ' I - ' - ' ' @ Greater number of elastin fibers. C. Lower concentration of glycosarninoglycans D. All of the above 1 1. Adhesive glycoproteins bind to which of the following? I _. t " Both of the above D. None of the above 12. Cellular adhesion regulates all of the following processes EXCEPT A. Morphogenesis CE Protein folding *1 V‘ C. Wound healing I I - _ I _..P ,'__' " .: . '1‘ - . '-.7|";7‘ ' 13. Cells regulate their capacity for adhesive interactions by 3- . i A. Secretion of cell adhesion molecules \ B. Increasing the metabolic rate C Expression of cell adhesion molecules on the surface . All of the above ' 14. “Contact inhibition” of cell growth is ./ Attributed largely to cadherins interactions . A key event in the malignant transformation C. Implicated in tumor metastasis D. All ofthe above 15. An example of integrin-containing cell junction is a A hemidesmosome B. A gap junctiOn C. An adherens junction D. A tight junction u.- I 6- ' A-'-".ialit‘a}ificuon- - @Des'inosome' ' ' ‘_ C. Hemidesmosomer D. Gap junction ’/ l7. Gap junction conductance'cap bé‘f'e‘g't'xldt AI Ca2+ . B. Phosphorylation _ ' 3- I a @ Both of the aboveI '2 I ' - D. None of the above 18. Mutations in connexin gen: m1 ht" \& Irregular heart beat v_‘. _ B. Lack of resting membrane potential 'l I C. Both'ofthe above’ I 3 5 D. None of the above ' a -- ,g' 19. DeSmoSomes attach epithelial cells to? A. Each other . ' ' B. The extracellular matrix @ Basal lamina D. All of the above 20. Adherens junctions are formed by ‘ Homophilic interactions of B. Heterophilic interactions of cadheljins._ ‘1‘:- ' . 13...:6t 'ophili ‘.'-.21:CYlo§keletbii"' . 1" A. Undergoes constant-managements“ \ B. Maintains cell structure ' .' ‘ - C. Is involved in movement of organelles in Q? All of the above , I .-_ 22. Polymerization of G actin - A. Is irreversible _ B Needs accessory proteins ' I I V . ' @Is‘accompanied by hydrolysis of ATP , . Can not happen outside of the cell ' " 23. Actin capping proteins . - _ A. Promote growth at the end they-attach__to - . Bind only to (+) end of actin-polymer" C. Are controlled by second meSS'engerthhways __ _ _ - j- . Depolymerize actin filaments; 7 ' . . , 3. ' ' ' I- -‘ .ha- _ 3‘...“ .-I”.r; ' ~ 2 .. Hue criticalconwntration for actin . . _ I. ,Concentrationbf G actin monomersi matron _ 25 . Which of the following is NOT a microtubule—based shyc'tiifg? . A. Mitotic spindle . ' figovim’n WW3» \C. , I. .4 - - iii... ' ‘ D. Flagella I 26. Which word best describes microtubule‘organization'in most-animal cells: .'_, _' ‘A. Random _ i 1 ' ' -. . '--_ L; - r " -_" ‘. 'Radial ' I _ .' __ _ . i'. _ .1 Linear ‘ I ' ‘ - '- 7‘. ' ‘ ‘ i '.I -. I D. Concentric ' ' . ' l I I‘m: 27. Triplet microtubules are found i ' ' A. Cilia and flagella <— Basal body and centrioles V LL ' _ . Axons of neuronal cells ~SW€7 \’ D. All of the above ' 28. The outermost layer of the skin (epidermis) is composed of Undifferentiated epidermal cells ' ‘ ._B. Basal stem cells _ > (9 Gross'éiinked keratinfilaments . " liagDéffc ‘ tedsniésnnslsells . . In “,5- - 29:?erich one of the followmg types of intermediate mMenis are; polarize A.‘ Keratin, ' - ' " v - ‘- g__- _. g B. Desmin .- C. Neurofilaments @ None of the above 30. Which statement of intermediate filaments is true? ‘ A. Intergrate cells into tissues ' B. Reinforce cells C. Are found in almost all eukaryotes 627 All of the above ’ ‘ ADK/ Amylfimml ("an/>9 ékaym Test3 , mg Psl’l. Mostsignslingpathwa I 83’ A 3. Linear only W38“ 3 b. Branching only c. Converging only - . y Branching and converging W l il’l 50m Cm d W A Her/u m (Mun (wow Stu/{@ch n Pub C W‘- ‘4 F“ heme aw i 3c 2 ML @9er 2. Which e following is TRUE about receptors? ” AW 1' , é“ receptors are proteins 1‘ \“wACL QcJQLQ «DRAG i medal; c2; ’y - “Wmmminhpmmbme \O Qaecu-onc no 9 3 ye} c. Receptors can be activated only by binding soluble ligands " ’ ‘ 3 1 Q“ fll‘hcre mmofdifi'erent receptor families in mammals 3 “3 f“ 9 Extracellular molecules X and Y bind to a plasma membrane receptor. Binding of molecule X results in changes in the cell’ behavior. Binding of molecule Y does not effect the cell’s behavior. y 3. Which ecule is an agonist‘? f2, 0 d , ,- ,’ Ii” .- Xv X ‘7 m ¥hlq~ c. . Neither X nor Y \M I 19w.) 056’de X [for 9 d. Both X and Y / “5p m»?— M 4. Which :iolggulc is an an‘étagonistgv‘ an MSG“) ) i blaghm b. Y 7 W VQBPWVR‘Q’ @ Neither X nor Y '- a He (2“ d. BotthndY X'i‘w no” 5. Which molecule isa ligand?— . i . ‘a. X ' I ' " - W.“ \< b. - Y 0.0:: c. Neither x nor Y / Both x and Y 61.1 Which of the following accurately describes RTK? .4 I. Dimcrization -) enzymatic activity of receptor , ‘ ' \0‘) Jam 11. am are main receptors for interleukins (<1 Ml?“ “9 “Q‘Wwi Oi (P in. Tyrosine kinase domain located extracellularly { M {CL “\‘UW “‘5’?” IV. TRK activates CAMP dependant signaling I only & b. land ll only G: PCML C. I, N r d. I, II, III, IV dew ~ 7. Which of the folldwing describes the effects of phosphorylation of proteins? axial?) 7~ ?_ 0 Phosphorylation typically occurs on serine and threonine residues v/U. Pliesphorylan'on creates binding sites (III; Phosphorylation can inhibirfifidilijg‘g’im IV. Phosphorylation refers to addition of alpha bhosphate residue from a. III, IV , . b I, u, w i) QM. Oi’ Cmiiwn’lohé‘f“ I. H, m r > A alierahm at mien-rm OAS M; i d. II, III ‘ t. L” P ‘3 ??'?inhjbits 7-‘helix receptorby... do k 5 C8 inwa. X I C\ “on l. 3 - A (r9) b. X en \ F 3 ) re gutsy ®Bloeking G protein interaction with receptor 59860 d. Stabilizmg the testing rate confonnauon 9. The G-protein is active only when bound to GDP. w . _ VM 0:” ' d W t h V 8 iv: 0 @M" “AM v2 r (-4 WW W5? *0 watqu '6 MP" 10. Which describes G-protein’s intnnsr' 'c GTPase activity? I g adv: Z - . . . 5 o P a. G—protein regulates its own gene cxpressxon ?°ZS fl G—protein hydrolyses GTP bound to terminate activity reguiU'L hi c. G—proteins phosphorylated themselves to induce enzymatic activity aria/mil vi d. G-proteins self assemble and disassemble to regulate enzymatic activity c idea/db - l 1. Which is TRUE concerning'adapter proteins? . _ A i _' ~ ' ' Mediate interactions of proteins with molecule “(XL 3R M W AK ‘-Are enzymes 400 opt—(1W0 45 c. Both of the above d. None of the above 12. Which domain specifically recognizes phosphorylated tyrosines? @ 7?? SH 2 , {film/ho iZ/rosml/lévxflt? b. I aberJ-In c' -Pe¥i7i he“ c. - p o - d. EVHl n ’” "MN? ”" i4“? 3H3 Wme nib/Chg: Q Uh UK 3( C, (mil—“dis 13. Choose correct statement concerning 2'Id messengers. 6 Ma av ‘ ‘ J F a. Lipid derived 2"d messengers are produced by enzymes called cyclases Pu L21 b. CAMP is involved in signaling pathwa by RTK s o .9ch ‘ 3 c. PIP; c release of Ca from intrace ular stores #— 1 . DAG and [Pg are derived from Phospholipid PIPz W iP/L— mifattiiuit/ I __. ..._.- . I] . l J' ' 4 ‘Ta (916. 229 . 1 14 . .9 O? CCL rel LL l4. Adenylyl cyclase generated cAMP from”. P mekw r? I \ of, :. ggenosine Precurs 0/ elg e ymg Reduces ‘ V \O “3 £7ATP lSJ‘hisenzyme degrades CAMP... I (ml oi“ a. Protein kinase - (WWW? addlh ex, 0%) Pl’lobphcde (“MA-re ray/deg _ way/5 @ Phosphodiesterase WK CVcla c nude» tides . ” PfiuWomflaug-q .95“; c. Adenylyl cycles: - malady/Mg bee/K9 f.th Hawker elem til 9 lo. c flag/C) d. Phosphorylase 16. March is the cellular efi'ecter of CM? 0 a. proteosorne . I ~ 9 01/27 @pmteinkinaseA _‘aK/AV § galeth eh (flan/I416). CWOFGE/i) _ W C. Adenylyl cyclase rig w ad. Phosphorylase I 17. Which ternent best describes 2“ messenger fitnction of NO? r k m 6’ o-i’ g3 NO relaxes smooth muscle by activating cGMP production (16“ ‘4‘ Q ’ (A # PC} ‘ b. NO regulates vasoconstriction thus increasing blood pressure Lv‘w W ’3 c. NO stimulates release of epinephrine 4’ Q fie/mam n 61,013, v 90 d. NO release Ca from intracellular stores 9 ,3 l p3 (21.9051CAQM‘W , Matching receptor types ‘ Camus-LCUAMW Morel/MW WWW/ll“ t“ V5 mm? 04% (em 18. Odorant an r t 19. Rhodopsin A J, Pan/1 4 e. 9le 20. Insulin recep v o . v ‘ r 21. Beta-adrenergic receptorQ b6 PCRE‘VS Gully,“ “my” WU’WQDL/e' - W>3"- DN‘? m J. a. [on channel receptor. _ i - ""' -‘ - (-JQPZ‘PJ‘J "‘ b. .RTK —* {Clack/11080:: KI/LK'UL c. Cytokine receptor . Y Wk ' d. GPCR_ G l’vo‘lem CWfl‘PJ “(Mm Side/6L 555/10 ‘ a mm 22. In pancreatic Beta cells, KAT}: ion channel closes in response to this ligand. a Ca aamaele ofll/l [Ll/Inple '\‘ g . b. Insulin e9 gagglecfi lot ° \”5 it“ . J6; Q c. Glucose «why. ‘V ATP cg ' . - “‘31) \l’lV‘l Leg!“ [MC 6 We 93° yellow “WW9 “M We} 23. Which is the signal transduction step in insulin~signaling cascade? a Binding of insulin to insulin receptor b. Desensitization of receptor 0 9 Recruitment of IRS protein by an insulin receptor » d. Insertion of GLUT 4 glucose uniportcrs in cell membrane 24. Which describes function of MAP Kim in insulin Signaling? m C ‘ a" CM“ insulin mm to mm x (y Regulates transcription factors for GLUT 4 Pm c. Stimulates glutamate secretion d. Activates ecosanoids to prodm Mandins 25. Which describes the condition of photoreceptor cel in dark? . 3- ROdS are hWW 'RocLS 0,43%!” lCW‘LQCfl tun (ti/mm" J0 b. Retinol is not attached to rhodopsin A V6/ 036 @CGMP channels stay open alto .-_ whinflux‘of a dCa d. bipolar cells are constantlyé‘ inhiblfio 26. What u . o - us when concentration of cGMP declines in photoreceptor cells? ? Glutamate secretion is inhibited . Cell membrane gets depolarized c. cGMP gated channels open d. rhodopsin is phosphorylated 27. Molecular properties of extracellular matrix determined by... The types of extracellular matrix moleculé m . Spatial arrangement of extracellular matrix molecules c ' Hydration level of extracellular matrix molecules ' l of the above 0 28. The basic unit of fibrillar callogen. .. ' Rx triple helix % ,7 Acoiled coil - . Aparallelhomodimer t. _ . a“ ‘ . _ Anantiparallelhomodimer' . ._ - .. 0 lb . 29. 41153811335: interaction occurs between which of the followmg molecules? a. Integrin and fibronectin 6b? N-cadherins on cells repressing similar N-cadherrins c. Selectin and mucin d. All of the above 30. Which doeescribe gap junctions? a. « ct as size filters \/ (‘ot’ll’l “W 5 b. Integrate metabolism between cells c. Can be regulated by pH Cd) Are present in chemical synapses ...
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This note was uploaded on 08/11/2008 for the course BIOL 3301 taught by Professor Wilk during the Spring '08 term at UT Arlington.

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cell_phys_ex3 - Test 3 1. Most signaling pathways are... a....

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