Cell Mol Biology Chapter 17 Summer 2017 - Alberts Bray Hopkin Johnson Lewis Raff Roberts Walter Essential Cell Biology FOURTH EDITION Chapter 17

Cell Mol Biology Chapter 17 Summer 2017 - Alberts Bray...

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Chapter 17 Cytoskeleton Essential Cell Biology FOURTH EDITION Copyright © Garland Science 2014 Alberts • Bray • Hopkin • Johnson • Lewis • Raff • Roberts • Walter
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Figure 17-1 Essential Cell Biology (© Garland Science 2014) The Cytoskeleton – the bones and muscles! Gives cell its shape Allows cell to move Allows organization of  internal organelles Microtubules ( Green ) Actin Filaments ( Red )
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Panel 17-2 Essential Cell Biology (© Garland Science 2014) Intermediate Filaments
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Panel 17-2 Essential Cell Biology (© Garland Science 2014) Microtubules
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Panel 17-2 Essential Cell Biology (© Garland Science 2014) Actin Filaments
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Intermediate Filaments
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Figure 17-3 Essential Cell Biology (© Garland Science 2014) Intermediate filaments form a strong  network in the cytoplasm Green =  Keratin  filaments Withstand mechanical stress when cells are stretched Toughest and most durable cytoskeletal filaments Surround nucleus and extend to periphery Anchored to plasma membrane at cell-cell junctions  (Desmosomes)  
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Twisted strands of  -helix form rope like  α structure Form  staggered  tetramers 8 of which coil  into a ropelike  filament!
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Figure 17-4 Essential Cell Biology (© Garland Science 2010) Filament structure strengthens the cell Cells which endure more mechanical stress have more filaments  (think muscles, skin, long thin nerve cells) Compare to reinforced concrete (has steel bars running through)
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Figure 17-5 Essential Cell Biology (© Garland Science 2014) 4 class of intermediate filaments Most diverse
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Figure 17-7 Essential Cell Biology (© Garland Science 2014) Plectin bundles intermediate filaments  connecting them to other cytoskeleton proteins Green – plectin      Red – microtubules      Blue -  intermediate filaments Act to further stabilize the filaments and link up the different  networks of structural proteins Mutations in pectin can cause muscular dystrophy and neuro  degeneration
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Figure 17-8 Essential Cell Biology (© Garland Science 2014)
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