Exam 3 KEY - Biochemistry 415/515 2008 March 27, 2008 Name...

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Biochemistry 415/515 2008 Name ________________________ March 27, 2008 uniqname________________________ Biochemistry 415/515 Exam 3 of 4 100 points total Instructions: 1. Please put your name on each page of the exam, your uniqname on the first page, and fill out the scantron sheet with your student ID number, name, and uniqname. 2. Read through the exam first. Answer the immediately obvious questions when you can. Put a question mark by the ones you’re not sure about. 3. Raise your hand to ask questions. Often you may be focusing on a phrase that can be stated differently. 4. If you’re still here after 60 minutes, get up and walk around for 2 minutes. Then start doing the test from back to front. Section A. Multiple choice (88 points - 2 points per question). Choose the most appropriate answer. 1. Membrane “pumps” a. allow ion flux down a concentration gradient b. transport ions and solutes against a concentration gradient c. use ATP as an energy source d. all of the above e. b and c only 2. What is true about gap junctions? a. they connect cells with surrounding fluid space b. they exchange small molecules only with extracellular fluids c. defects in gap junction protein connexin 26 are associated with deafness d. gangliosides are the major gap junction proteins e. all of the above 3. What is true about gangliosides? a. they are composed of ceramide and acidic sugars b. Tay-Sachs disease is caused by failure to synthesize gangliosides c. they primarily reside on the cytoplasmic side of the membrane d. all of the above e. a and b only 4. In cholesterol synthesis a. all carbons are derived from acetyl CoA b. malonyl CoA is an important intermediate c. activated isoprenes are important intermediates d. all of the above e. a and c only Exam 3 Page 1
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Biochemistry 415/515 2008 Name ________________________ March 27, 2008 uniqname________________________ 5. HMG-CoA reductase is a. a target of statin drugs b. regulated via degradation of the protein c. regulated via the synthesis of the protein d. all of the above e. a and b only 6. In the transport of lipids and cholesterol a. chylomicrons are the major cholesterol carriers and LDL the scavengers b. HDL are the major cholesterol carriers and LDL the scavengers c. chylomicrons are the major cholesterol carriers and HDL the scavengers d. HDL are the major cholesterol carriers and chylomicrons the scavengers e. LDL are the major cholesterol carriers and HDL the scavengers 7. Steroid hormones a. are synthesized from cholesterol by chain shortening and hydroxylations b. target receptors in the nucleus c. P450 mono-oxygenases catalyze hydroxylation reactions for their synthesis d. all of the above e. a and c only 8. Signal transduction (transmembrane signaling) by epinephrine-type hormones involves a. 7-transmembrane receptors b. amplification c. second messengers and phosphorylations d. all of the above e. a and c only 9. Calmodulin a. carries out phosphorylations in signal transduction cascades b. is a calcium sensor
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This note was uploaded on 09/11/2008 for the course BIOLCHEM 415 taught by Professor Michaeluhler during the Spring '06 term at University of Michigan.

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Exam 3 KEY - Biochemistry 415/515 2008 March 27, 2008 Name...

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