Novel drug delivery 2

Novel drug delivery 2 - Novel drug delivery(2 PHA...

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Dr. Dube [email protected] Office 3.19 Novel drug delivery (2) PHA 431/PHA411
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Outline Microencapsulation Diffusion controlled systems Dissolution controlled systems Osmotic systems Floating drug delivery systems
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Microencapsulation Individual, micron-sized, particles (of solid, liquid or gas) enclosed in a sheet of inert polymeric material. Encapsulating drug. Sizes vary (1 – several hundred micrometers)
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Rationale for Microcapsules To enhance the stability and solubility of drugs (ultimately improve bioavailability) Separate incompatible components. Modulate drug release kinetics Masking of bitter taste. Masking of unpleasant odours. Decrease potential handling danger for toxic substances.
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Microencapsulation preparation methods Coacervation Mechanical methods Interfacial polymerisation Electrostatic methods
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Coacervation The most common method used. Describes the process of formation of a colloidal state - intermediate between a true solution and a solid precipitate Definition of coacervation: separation of a colloid rich layer from a lyophilic sol on addition of another substance Also known as phase separation Three step process: Formation of three immiscible chemical phases. Deposition of polymer coating. Rigidisation of coating.
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Phase separation Drug is suspended in a solution of the coating material. Non-solvent liquid is added and the mixture is stirred. Appropriate conditions (stirrer speed and rate of solvent addition) results in coacervation of coating material on drug.
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