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Unformatted text preview: sequence similarity. If the hypothetical gene's sequence is seen to be similar to that of a gene of known function, scientists may be able to predict what protein it should make, based on information they have about the known gene. They may be able to predict the amino acid sequence of the hypothetical protein as well as its function, based on what is known about other proteins with similar sequences. Exercise II, part 1 (a) MSH2, 2p22p21; MSH6, 2p6.3 (b) MSH2 and MSH3 encode DNAbinding proteins that are involved in mismatch repair of DNA. (c) Mutations of MSH2 and MSH6 genes on chromosome 2 are associated with colon cancer. (d) Muta...
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- Spring '08