genetics4

Genetics4 - Genetics Homework 4 due in lecture Tuesday Sept 2 1 Six evolutionarily related but separate species each arose through a single

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Unformatted text preview: Genetics Homework 4 due in lecture Tuesday, Sept. 2 1. Six evolutionarily related but separate species each arose through a single inversion in a chromosome of its predecessor. The progenitor species had the chromosomal composition of ABCDEFGH. The following represent the chromosomes from the related species (not in order of how they arose): (1) AEBGHDFC (2) AEDHGFBC (3) AEBGFDHC (4) AEDCBFGH (5) AEDHGBFC Show how the 5 species arose from the original progenitor by indicating where the inversions occurred. 2. Wildtype phage T4 grows on both E. coli B and E. coli K12(), producing turbid plaques. The rII mutants of T4 grow on E. coli B, producing clear plaques, but do not grow on E. coli K12(). This host range property permits the detection of a very low number of r+ phages among a large number of rII phages. With such a sensitive system, it is possible to determine the genetic distance between two mutations within the same gene in this case, the rII locus. Suppose E. coli B is mixedly infected with rIIx and rIIy, two separate mutations in the rII locus. Suitable dilutions of progeny phages are plated on E. coli B and E. coli K12(). A 0.1ml sample of a thousandfold dilution plated on E. coli B produces 672 plaques. A 0.2ml sample of undiluted phage plated on E. coli K12() produces 470 turbid plaques. What is the genetic distance between the two rII mutants? 3. Exploring Genomics, chapter 8, page 221222. ...
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This note was uploaded on 09/12/2008 for the course BICD 100 taught by Professor Nehring during the Summer '08 term at UCSD.

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