K12. Neuroscience OAINS - dr.Darmawan, M.Kes, Sp.PD

K12. Neuroscience OAINS - dr.Darmawan, M.Kes, Sp.PD -...

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ANTIPYRETICS-ANALGETICS Darmawan,dr.,M.Kes,Sp.PD
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PROSTAGLANDINS Produced in minute quantities by all tissues Generally act locally Synthesis Archidonic acid Componentof the phospholipids of cell membranes, esp: phospatidylinositol Released by the action of phospolipaseA2
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PROSTAGLANDINS Synthesis Cyclooxygenase pathway Incl: thromboxanes and prostacyclins COX1-COX2 -> PG Lipoxygenase pathway To form 5HPETE, 12-HPETE, 15-HPETE -> Leukotrienes
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NSAID NSAIDs: Nonsteroidal Antiinflammatory Drugs Antiinflammatory, analgesic, and antipyretic Mechanism of Action and Therapeutic Effects of NSAIDs inhibitedthe enzymatic productionof prostaglandins higher concentrations,SOD, induceapoptosis, inhibit the expression of adhesion molecules, decrease nitric oxide synthase, decrease cytokines ( e.g., TNF-, interleukin-1),modify lymphocyte activity, and alter cellular membrane functions
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NSAID Antipyretics, Analgesics, Anti-inflammatory activities
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  • Spring '17
  • Andriani
  • Paracetamol, Non-steroidal anti-inflammatory drug, Incl, blood brain barrier, thermoregulatory center

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