Unformatted text preview: The inheritance of hypercholesterolemia:
Hypercholesterolemia results in high levels of cholesterol in the blood stream despite exercise and diet life styles that should decrease blood cholesterol levels. Individuals homozygous for the defective allele have
no functional LDL receptors on their somatic cells and develop cardiovascular disease by the time they
are teenagers. Individuals heterozygous for the defective allele have half the normal number of
functional LDL receptors on their somatic cells and develop cardiovascular disease in their thirties.
Individuals homozygous normal have the normal number of functional LDL receptors on their somatic
cells and do not develop cardiovascular disease until their fifties. There is no difference in the inheritance
pattern observed in men and women. 19. Is the pattern of inheritance for hypercholesterolemia autosomal or sex-linked? (j 0'13 zsifglt/Lal __ 20. Is this pattern of inheritance codominant or incompletely dominant? COC'zWi/‘CVH' 21. Using the symbols H, and H2, deﬁne the diploid genotypes and corresponding phenotypes for this trait.
Clearly indicate which column is genotype and which column is phenotype. (4 points)
(Note there are three different phenotypes shown above in bold type.) Genotype wit/WW _ ‘ it H, MD . alto/MI 0:12:33: Hi H; ”0.1% time 41’ orp DL 1” ,4
ta‘lti new! Via/lit)” (if (Anew! LDL» 22. A woman heterozygous for hypercholesterolemia has a child with a man who has completely normal
LDL receptors. Identify the parental genotypes, phenotypes, and gametes for this cross. (6 points) ,7
Q PARENT 1 PARENT 20/
”A? tum, NW", 40¢ PARENTAL GENOTYPES: ”I #1- Hi #2 GAMETES: ii) iii Q13 QED PARENTAL PHENOTYPES: 1') L/
24. What is the probability that their child will have no functional LDL receptors? _ [le __
25. What is the probability that their child will have some functional LDL receptors? _/3 __ 26. What is the probability that their child will have the normal number of functional LDL receptors? ...
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- Spring '08