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Chapter 6 - About my VPHY3100 My contact information Dr...

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Wells/VPHY3100/Fall08 About my VPHY3100… My contact information Dr. Wells [email protected] 706-202-8715 Room 2220 Vet Med Bldg You are responsible for reading the entire chapter prior to the first lecture associated with that chapter My PPT lectures will be available on WebCT at least 24 hours in advance My office hours NOT 2:15 - 3:15 MWF 12:30 - 1:15 MF (not Wed) Otherwise by appointment (email me well in advance)
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Wells/VPHY3100/Fall08 About my VPHY3100… Sign & hand in your Quiz Form this week Pop quizzes will occur at the end of the class period. There will be NO MAKE-UPS. Rain Check Policy Some questions are “rain checks”, but others are not Please raise your hand Rain check = 8.5 x 11 sheet of paper with date, question, answer, and my signature (get at end of class) Retain your rain check until the end of the semester Only one rain check per student per semester
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CHAPTER 6: Interactions Between Cells & the Extracellular Environment K. Wells, Fall 2008 VPHY3100: Elements of Physiology Dept. Physiology & Pharmacology College Vet. Med.
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Wells/VPHY3100/Fall08 Chapter outline The cell: inside & out The extracellular environment Movement through the cell membrane: diffusion & osmosis Movement through the cell membrane: carrier-mediated transport Movement via vesicular fusion The membrane potential Cell signaling
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The cell FIGURE 3.1
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http://catalog.nucleusinc.com/generateexhibit.php?ID=14600 http://www.biochem.mpg.de/en/rd/fromherz/publications/99vasfro/ http://original.britannica.com/eb/art-56763/ Some real cells…
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Wells/VPHY3100/Fall08 The cell: inside & out The cell Cytoplasm Cytosol Organelles Nucleus Cell (or plasma) membrane The extracellular space FIGURE 3.2 Inside of cell Outside of cell
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Wells/VPHY3100/Fall08 Chapter outline The cell: inside & out The extracellular environment Movement through the cell membrane: diffusion & osmosis Movement through the cell membrane: carrier-mediated transport Movement via vesicular fusion The membrane potential Cell signaling
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Wells/VPHY3100/Fall08 The extracellular environment The cell membrane acts as a physical barrier between the cytoplasm (inside of the cell) and the extracellular fluid (ECF, outside of the cell) Living organisms are ≥ 70% water by weight! Total body water is divided between: Intracellular compartments (~67%) Extracellular compartments (~33%) 20% as vascular fluid (blood plasma) 80% as interstitial fluid (non-vascular “tissue fluid” that resides within the extracellular matrix)
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Wells/VPHY3100/Fall08 Extracellular & intracellular compartments FIGURE 14.8
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The extracellular environment The extracellular environment includes everything that lies outside of cells The ECM, or extracellular matrix: Gel-like hydrated material “Ground substance” Glycoproteins (such as integrins) Proteoglycans Protein fibers Collagen Elastin
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Selective permeability of cell membranes Simple diffusion Carrier- mediated transport Lodish et al., Molecular Cell Biology, 5th Ed.
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