PHARMACOLOGYFLASHCARDS.DQ

PHARMACOLOGYFLASHCARDS.DQ - INOTROPES Influence the force...

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INOTROPES: Influence the force of muscular contractions of the heart Positive inotropes: ↑ the force of myocardial contraction/ tx of failing heart muscle Negative inotropes: the force of contraction Positive chronotropics: heart rate Dromotropics: accelerate conduction Dopamine: cardiac glycoside- help control ventricular response to A-fib. myocardial contractility. 2 nd ary to inhibition of Na- K pump cellular Na & Ca. Vagal tone diastolic filling between heartbeats, prolongs refractory period HR & improves cardiac efficiency./ Given for: Tx. Systolic HF, & A fib. 0.5-2ng/ml level. K-Mg may potential for toxicity. Digifib/ antidote for overdose Isoproterenol: + inotrope/chronotropic HR, 0/ MAP, PAP, 0/ PAWP, CVP, SVR Amrinone lactate: INOCOR : 0 HR, MAP, PAP, PAWP, SVR, 0/ CPP, SV Milrinone: PRIMACOR : short term use ICU. AHF.
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DIRECT VASODILATORS: relax arteriolar &/or venous smooth muscle relaxation BP Able to directly cause peripheral vasodilation SVR/ systemic vascular resistance. Nitroprusside/ NIPRIDE, NITROPRESS. ICU for severe HTN emergency. Titrated by IV infusion. C/I in pts with severe HF & inadequate cerebral perfusion. HR, SV, MAP, PAP, & SVR. 0/ PAWP, CVP Hydralazine/APRESOLINE: can be given PO. C/I CAD, mitral valve dysfunction. HR, MAP, PAP, SVR. 0/ PAWP, CVP. Nitroglycerin: TX OF ISCHEMIC HEART CONDITIONS/ ANGINA. Has large 1 st pass effect. Sublingual, stored in their container. Relaxes smooth muscle dilation of large & small coronary arteries redistribution of blood & O2 to ischemic myocardial tissue angina sx./ venous dilation venous return L ventricular end diastolic vol./ PRELOAD
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