micro chapter 20 2015 - ANTIMICROBIAL DRUGS Q&A This...

Info icon This preview shows pages 1–16. Sign up to view the full content.

View Full Document Right Arrow Icon
ANTIMICROBIAL DRUGS
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This bacterium is lysing because an antibiotic disrupted its cell wall. Why doesn’t the antibiotic lyse human cells? Q&A
Image of page 2
Chemotherapy : The use of drugs to treat a disease Chemotheraputic drugs include synthetic drugs and antibiotics . Antimicrobial drugs : Interfere with the growth of microbes within a host Antibiotic : A substance produced by a microbe that, in small amounts, inhibits another microbe(produced naturally) Synthetic drugs are created in a laboratory. Selective toxicity : A drug that kills harmful microbes without damaging the host (drugs working against prokaryotic and youre eukaryotic) Antimicrobial Drugs
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
1928 : Fleming discovered penicillin, produced by Penicillium Wasn’t until 1940 : Howard Florey and Ernst Chain performed first clinical trials of penicillin Antimicrobial Drugs
Image of page 4
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Broad spectrum Narrow spectrum Superinfection Normal flora is replaced with an antibiotic resistant strain ex staph aureus , mrsa The Spectrum of Antimicrobial Activity
Image of page 6
The Action of Antimicrobial Drugs The actions of antimicrobial drugs are either bactericidal (Kill)or bacteriostatic (slow growth rate) 5 ways to inhibit microorganisms 1. Inhibition of cell wall synthesis. 2. Inhibition of protein synthesis. 3. Injury to plasma membranes. 4. Inhibition of nucleic acid synthesis. 5. Inhibition of Essential
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The Action of Antimicrobial Drugs
Image of page 8
This bacterium is lysing because an antibiotic disrupted its cell wall. Why doesn’t the antibiotic lyse human cells? Q&A
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Penicillin(antibacterial) (most common) general term split into 3 groups Natural penicillins Semisynthetic penicillins Extended-spectrum penicillins Inhibitors of Cell Wall Synthesis
Image of page 10
The Structure of Penicillins Rapidly excreted Narrow spectrum of activity Susceptible to penicillinases
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The Structure of Penicillins Ususally more broad spectrum Greater retention time More resistant to penicillinases
Image of page 12
Retention of Penicillin G
Image of page 13

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The Effect of Penicillinase on Penicillins ( -lactamase)
Image of page 14
Image of page 15

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 16
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern