6 DNA structure

6 DNA structure - DNA as the hereditary material Nucleic...

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DNA as the hereditary material Nucleic acid structure Reading: Ch. 3 pp 57-60 Ch. 11 pp 232-241 Recommended: Watson and Crick original paper on the structure of DNA ( Nature 4356:737 (1953) Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid )
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Learning Objectives After this lecture you should be able to: Draw the structure of DNA using symbols for deoxyribose, the bases and phosphate groups. Begin to understand the polarity (5’ vs. 3’) inherent in DNA structure and the significance of that polarity. Understand the key experiments and historical context leading up to the discovery of DNA as the heritable material.
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Human genome trivia Human genome contains 3,000,000,000 nucleotide pairs (bp) Smallest known genome = 600,000 bp Human genome estimated to contain 20,000- 35,000 genes Average human gene is 3,000 bp Genes are thought to comprise only about 2% of the human genome 99.9% of these bases are the same in all people.
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DNA D eoxyribon ucleic a cid. Familiar double helix structure In cells, DNA is the hereditary material--the blueprint for design that gets passed from generation to generation One of the most important human discoveries
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Triphosphate
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Chemical Composition of Nucleotides
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5’ 3’
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Triphosphate
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6 DNA structure - DNA as the hereditary material Nucleic...

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