studylist14 - transferred to FMN and then to Fe-S cluster,...

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Study list 14 Know the composition of the electron transfer chain (complex I, II, III, IV) and their orders. You should understand how the electron chain was identified experimentally. For example, you should know how inhibitors are used to dissect the electron transfer chain. You should also know how redox potential can be used to determine relative positions of electron carriers in the electron transfer chain. You should know how electrons can be transferred from one complex to another complex, given that the complexes are very big and may not contact each other directly. For each complex, you should know where the electrons come from and what is the ultimate electron acceptor. For example, you should know for complex I, the electrons come from NADH and the final electron acceptor is coenzyme Q. There is no need to memorize the detailed electron transfer order within a complex, but you should understand the logic behind it. For example, you do not need to memorize the following order: electrons are
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Unformatted text preview: transferred to FMN and then to Fe-S cluster, and then to Q. However, you should understand why electrons have to be transferred from NADH to FMN first and why not directly to Fe-S clusters. Understand why reduction of Q to QH2 can be coupled with the uptake of two protons from the matrix. Know what is the complex II (the electron donor and the electron acceptor). Again, why electrons have to be transferred to a flavin before they are transferred to Fe-S clusters. Know that electrons from complex I do not go through complex II. Both complex I and complex II are used to reduce coenzyme Q, but the initial electron donors are different (NADH vs succinate). Understand why oxidation of FADH2 ALWAYS yield fewer ATPs than oxidation of NADH Know the electron carriers in complex III (heme, Fe-S clusters). NO need to memorize the names of the heme proteins except cytochrome c. Understand what is a Q cycle and the relationship between Q cycle and proton pumping...
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This note was uploaded on 09/16/2008 for the course BIBC 102 taught by Professor Price during the Fall '02 term at UCSD.

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