Chapter 1 Introduction To The Study Of Cell

Chapter 1 Introduction To The Study Of Cell - CHAPTER 1...

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HAPTER  1 I NTRODUCTION  T O  T HE  S TUDY  O F  C ELL OLECULAR  B IOLOGY Introduction I. Cell & molecular biology is reductionist – based on the view that knowledge of the parts of the whole can explain the character of the whole A. Can lead to replacement of the wonder & mystery of life by the need to explain everything in terms of the workings of the machinery of living systems which many consider a loss B. Can replace this loss by a strong appreciation for the beauty & complexity of the mechanism underlying cellular activity II. A. Spectacles were first made in Europe in the 13 th century B. First compound (double-lensed) microscopes were made by the end of the 16 th century C. By the mid-1600s, a handful of scientists had used handmade microscopes to uncover a previously unseen world The Discovery of Cells I. Robert Hooke (1665), English microscopist (at age 27, became curator of the Royal Society) A. Described chambers in cork (part of the bark of trees); called them cells (cellulae) since they reminded him of cells occupied by monks living in a monastery B. Found them while trying to explain why cork stoppers could hold air in a bottle so effectively C. Was looking at empty cell walls of dead plant tissue; no internal structure – walls originally made by the living cells they surrounded II. Anton van Leeuwenhoek (1665-1675), Dutch seller of clothes & buttons – in spare time, he ground lenses & made microscopes of remarkable quality A. He was the first to describe living single cells; his results were checked and confirmed by Hooke B. Saw “animalcules” in pond water (first to do this) using the scopes that he made C. D. IV. A. Matthias Schleiden, German lawyer turned botanist (1838) – realized that, despite differences in tissue B. Theodor Schwann, German zoologist (1839) realized cellular basis of animal life; concluded that C. Schwann then proposed first two tenets of Cell Theory 1. All organisms are composed of one or more cells. 2. The cell is the structural unit of life for all organisms . D. However, the Schleiden-Schwann view of cell origin was less insightful - both felt cells could arise from noncellular materials -> eventually disproved by others; it took time due to their prominence E. derived from his cell division observations; it ran counter to Schleiden-Schwann view of cell origins 1. Cells can arise only by division from a preexisting cell . Basic Properties of Cells
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Chapter 1 Introduction To The Study Of Cell - CHAPTER 1...

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