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NTbiosynthesis2_web

NTbiosynthesis2_web - Nucleotide Biosynthesis N2 Fixation...

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Nucleotide Biosynthesis N 2 Fixation Pentose Phosphate Pathway Ribose Amino Acid Biosynthesis Glutamate / Glutamine Nucleotide Biosynthesis Urea Cycle Gluconeogenesis Citric Acid Cycle and Others
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Nucleotides can be synthesized by de novo or salvage pathways. We will focus on de novo synthesis.
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(5-phospho-ribosyl-1- pyrophosphate) Pyrimidine Biosynthesis: Overview
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Step 1: Step 2: Reactions catalyzed by CPS
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We won’t discuss the urea cycle, but the major products are fumarate, which is used in gluconeogenesis, and urea.
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Formation of orotate from carbamoyl phosphate and aspartate ATCase Dihydroorotase Dihydroorotate dehydrogenase Aspartate
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{Note the α -configuration of the pyrophosphate group}
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DNA RNA ATP GTP CTP UTP dTTP Purine Nucleotides Pyrimidine Nucleotides PRPP Purine Biosynthesis Pyrimidine Biosynthesis Purine Salvage Pyrimidine Salvage NAD + Biosynthesis Histidine Biosynthesis Tryptophan Biosynthesis Regulation of Gene Expression
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Orotate is then attached to PRPP to form Orotidylate.
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