Drug name: Clotrimazole, Mycelex Classification: Therapeutic: antifungal (oral, non-absorbed) Reason for taking: Treatment of oropharyngeal candidiasis. Prevention of oropharyngeal candidiasis in immunocompromised patients (receiving chemotherapy or radiation for cancer or corticosteroids for cancer or transplant). Dosing, Route, Frequency: PO: (Adults and children older than 3): Treatment – One troche 5 times daily for 14 days; Prophylaxis – One Troche 3 times daily for the duration of chemotherapy or until steroid doses are reduced to maintenance levels. CONTRAINDICATIONS: Contraindicated in hypersensitivity to clotrimazole or other components of formulation; systemic candidiasis. Use cautiously in hepatic impairment; OB: Use only if potential benefit justifies potential risk to fetus; Pedi: Children under 3 safety and effectiveness not established. SIDE EFFECTS: GI: abnormal mouth sensations, increased liver function tests, nausea, vomiting. Derm: pruritis. Half Life: 24 hours NURSING CONSIDERATIONS: Instruct patient to take clotrimazole as directed. Allow each troche to slowly dissolve in mouth to achieve maximum effect. Indications: Impaired roral mucous membrane. Assess oropharyngeal mucosa prior to and periodically during therapy. Monitor hepatic function prior to and periodically during therapy. May cause increased AST. Drug name: Fluconazole, Canesoral, Diflucan, Diflucan One, Monicure Classification: Therapeutic: Antifungals (systemic) Reason for taking: Inhibits synthesis of fungal sterols, a necessary component of the cell membrane. Therapeutic effects: Fungistatic action against susceptible organisms. May be fungicidal in higher concentrations. Prevention of recurrent vaginal yeast infections. Dosing, Route, Frequency: PO: IV: (Adults): 200 mg initially, then 100mg daily for at least 2 weeks. PO: IV: (Children greater than 14 days): 6 mg/kg initially, then 3 mg/kg/day for at least 2 weeks. PO: IV: (Neonates less than 14 days, 30-36 weeks’ gestation): same dose as older children except frequency is q 48 hour; Premature neonates less than 29week gestation: 5-6 mg/kg/dose every 48-72 hour. CONTRAINDICATIONS: Contraindicated in: Hypersensitivity to fluconazole or other azole antifungals; Concurrent use with pimozide, erythromycin, or quinidine. SIDE EFFECTS: Incidence of adverse reactions is increased in HIV patients. CNS: Headache, dizziness, seizures. GI: Hepatotoxicity, abdominal discomfort, diarrhea, nausea, vomiting. Derm: exfoliative skin disorders including stevens-johnson syndrome. Endo: hypokalemia, hypertriglyceridemia. Misc: allergic eractions, including anaphylaxis. Half Life: Premature neonates: 46-74 hour; children 19-25 hour (PO) and 15-17 hour (IV); Adults: 30 Hour (increase in renal impairment). NURSING CONSIDERATIONS: Instruct patient to take medication as directed, even if feeling better.
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- Summer '16
- Nursing, Herpes simplex, Nursing Considerations, Candidiasis, Reverse transcriptase inhibitor