118Lecture07_08_ - Antibiotics Prophylaxis or Treatment?...

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Antibiotics Prophylaxis or Treatment?
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Antibiotic Resistant Bacteria Analogy of the armor-piercing shells and the tanks Moral: beware of the single exception Analogy of the Hannibal and the elephants Moral: it only works once
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Vaccines Prophylaxis or Treatment?
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Timing and vaccination Takes time for vaccines to “take” Differs for different vaccines Sometimes partial protection Need to know the enemy in advance Partial resistance usually defends against vaccine resistance But smallpox vs. HIV
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Anthrax Bacillus anthracis
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Bacillus anthracis Cause of anthrax Found in soil Pathogenic for grazing animals Humans get if from animals (or from intentional inoculation) B. anthracis makes spores that are very hardy survivors
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Spores Designed for survival Non-growing (dormant) state Very little water Hard outer shell Smaller than growing cells If a cell is a cocktail sausage, a spore is a marble
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B. anthracis with spores
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118Lecture07_08_ - Antibiotics Prophylaxis or Treatment?...

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