22 - 1/22 Tuberculin Reaction Inoculate a guinea pig with...

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1/22 Tuberculin Reaction Inoculate a guinea pig with M. tuberculosis, lesion heals quickly but the animal dies later Inoculate a previously exposed animal, the lesion ulcerates, but does not spread Tuberculin skin test Koch thought this was a vaccine, wrong For populations that have not been vaccinated with BCG, it tells exposed or not (if you have antibodies, you react, if you’ve never seen M. tuberculosis you don’t) BCG (Bacille Calmette and Guerin) Late 1890’s knew of “attenuated” vaccine (rabies) Destroys utility of tuberculin skin test Most widely used ever (about 3 billion people have been vaccinated) Safe Efficiency ranges from a few % to 95% (this must be grown which might be the difference in successes) It is constantly evolving Chemotherapy (magic bullets) 1944 Streptomycin (Waksman) o this kills most bacteria 1952 Isoniazid (Robitzek and Selikoff) Bubonic Plague Has three European visits Plague of Justinian Population was basically cut in half
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This note was uploaded on 09/22/2008 for the course BIO 118 taught by Professor Bender during the Spring '08 term at University of Michigan.

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22 - 1/22 Tuberculin Reaction Inoculate a guinea pig with...

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