NURS-6501C: Advanced Pathophysiology WEEK 8 Pathophysiology According to Huether and McCance (2017), ulcerative colitis (UC) and Crohn disease (CD) are chronic inflammatory bowel diseases. UC is a chronic disease that causes ulceration of the colonic mucosa, mostly in the rectum and sigmoid colon producing large volumes of watery diarrhea (Huether and McCance, 2017). UC starts with a lesion causing inflammation at the base of the crypt of Liberkuhn in the large intestine (Huether & McCance, 2017). It begins in the rectum and can extend across the whole colon; the mucosa is hyperemic and may appear dark red and velvety, the small erosions forms coalesce into ulcers (Huether & McCance, 2017). Therefore, there is abscess formation, necrosis, and ragged ulceration of the mucosae, which lead to edema and thickening of the muscularis mucosae that narrow the lumen of the colon (Huether & McCance, 2017). Crohn’s disease is an idiopathic inflammatory disorder that affects any part of the gastrointestinal tract from the mouth to the anus (Huether & McCance, 2017). Inflammation begins in the intestinal submucosa and spreads with transmural involvement (Huether & McCance, 2017). The ulcerations of CD can produce fissures that extend inflammation into
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- Spring '19
- Irritable bowel syndrome, Ulcerative colitis, Crohn's disease, Huether