chapter 1 notes expanded

chapter 1 notes expanded - 9/4/2008 Peter Parham The Immune...

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9/4/2008 1 The Immune System Second Edition Chapter 1 Elements of the Immune System and their Roles in Defense Copyright © 2005 by Garland Science Publishing Peter Parham Diseases caused by a disturbed immune system Allergy Normal bronchiole Bronchiole in asthma Bronchiole in asthma Mast cells in asthma
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9/4/2008 2 Normal nose Autoimmunity Normal salivary gland Sjogren’s Syndrome salivary gland Sjogren’s Syndrome Systemic Lupus Erythematosus
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9/4/2008 3 Autoimmunity: Rheumatoid Arthritis Normal stomach Autoimmune gastritis (anti-parietal cell Ab) Autoimmunity Myositis Pemphigus vulgaris Intercellular IgG staining
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9/4/2008 4 Immunological damage in the kidney Normal glomerulus Goodpasture’s syndrome (linear staining) IgA nephropathy (mesangial area staining) Post streptococcal GN (lumpy bumpy staining) Endothelial rejection of grafted cornea Normal kidney Rejecting kidney (tubulointerstitial) Normal heart Rejecting heart Graft rejection
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9/4/2008 5 Acquired Immune Deficiency Bone marrow transplantation Bubble Boy Immune Deficiency General scheme of an immune response Both humans and pathogens are made of Most microorganisms do not cause disease in humans How does the human immune system distinguish pathogens from human tissues and harmless microorganisms? Pathogens Disease - causing organisms Protozoa, Bacteria, Viruses, Fungi, Worms etc
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9/4/2008 6 Figure 1-1 Vaccine induced strong immunity Humans are the only host Most humans vaccinated Figure 1-2
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7 Figure 1-3 part 1 of 4 Schistosoma mansoni – 5X worm Trypanosoma brucei– 1750X protozoan Pneumocystis carinii– 720X Fungus-SIDS
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chapter 1 notes expanded - 9/4/2008 Peter Parham The Immune...

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