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Metabolism - BILD 1 sp08 Lecture 8 Metabolism Preview...

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BILD 1, sp08 Lecture 8 4-24-2008 Metabolism
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Preview Metabolism Free energy change (ΔG) Energy coupling Enzymes Activation vs Inhibition ATP production
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Metabolism: Totality of an organism’s chemical reactions
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Metabolism in Action colby.edu "Once tryptophan is consumed, it breaks down via different metabolic pathways to form a huge number of proteins and hormones, including serotonin, which elevates mood, and melatonin, which promotes sleep - a partial explanation for the nap that often follows Thanksgiving dinner. Tryptophan also helps make an essential vitamin, niacin."
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Metabolism The totality of chemical reactions and energy output/input in an organism In metabolism, macromolecules get made (energy is consumed), and macromolecules get degraded (energy is released). Free energy change (ΔG)= thermodynamic formula stating whether energy is consumed or released Where a chemical reaction goes REACTANT PRODUCT, ΔG = G product – G reactant If ΔG > 0 , energy is consumed If ΔG < 0 , energy is released ( spontaneous )
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Energy is released in this reaction ( spontaneous ) Reactants Products Energy Progress of the reaction Amount of energy released (∆ G <0) Free energy Energy Products Amount of energy released (∆ G >0) Progress of the reaction Reactants Free energy Energy is required (i.e.consumed) in this reaction ΔG = G product - G reactant
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Structure of adenosine triphosphate (ATP) CH O O O O CH 2 H OH OH H N H H O N C HC N C C N NH 2 Adenine Ribose O O O O O O P P P Phosphate groups
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